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rna-seqblog.com /1 month ago

Long-read RNA sequencing reveals how alternative splicing shapes immune responses

Long-read RNA sequencing revealed extensive alternative splicing changes in activated human monocytes, uncovering functional isoforms that enhance immune protein production during...

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journals.plos.org /3 weeks ago

Beyond the canonical: The role of post-transcriptional regulation in drug-target interaction prediction

by Md Istiaq Ansari, Khandakar Tanvir Ahmed, Debby D. Wang, Kirill Medvedev, Wei Zhang Protein isoforms produced from the same gene through post-transcriptional regulatory mechani...

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rna-seqblog.com /1 month ago

A hidden switch fine-tunes the heart’s elasticity

RNA sequencing reveals that RBM20 uses multiple transcription start sites, producing distinct protein isoforms that influence heart development, cardiomyopathy, and heart muscle fu...

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bioengineer.org /1 month ago

RBM20 Isoform Control Shapes Splicing in Health

In the intricate landscape of genetic regulation, the study of RNA-binding proteins is unraveling new dimensions of molecular control mechanisms pivotal for development and disease...

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rna-seqblog.com /1 month ago

HELIX – a scalable model for predicting context-dependent regulation of RNA splicing and isoform usage

RNA sequencing combined with deep learning enabled HELIX to predict tissue-specific splicing patterns, transcript isoforms, and patient-specific splicing changes in cancer...

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rna-seqblog.com /1 month ago

Generative modeling for RNA splicing prediction and design

Combining RNA sequencing data with generative AI, TrASPr+BOS predicts and designs tissue-specific splicing outcomes, helping researchers explore gene regulation and potential RNA t...

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rna-seqblog.com /2 weeks ago

Combining AI and RNA analysis improves detection of disease-causing splicing variants

Combining computational tools with functional RNA sequencing improves interpretation of disease-causing splicing variants and highlights the importance of transcript-level validati...

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genengnews.com /1 month ago

Immune Response Activated by RNA Splicing Opens Targeted Therapies

Researchers have uncovered a previously underappreciated mechanism, where RNA splicing plays a central role in shaping immune response. The results provide insights into immune-med...

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journals.plos.org /2 weeks ago

Splicing deficiency is driven by genomic erosion in non-recombining algal mating-type chromosomes

by Chris Condon, Andrea Galvez, Alexander Kramer, Landen Gozashti, Chris Vollmers, Manuel Ares Jr., Russell Corbett-Detig Splicing deficiency may represent a critical yet underexp...

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