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journals.plos.org /1 month ago

The kinetoplastid-specific transcription factor mtTF1 is essential for mitochondrial gene expression and maxicircle repl...

by Bianca Manuela Berger, Enrico Santini, Himaja Manjunatha, Lea Trost, Markus Gerber, Hauke S. Hillen, Torsten Ochsenreiter Mitochondrial DNA replication and gene expression are...

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journals.plos.org /1 month ago

Post-transcriptional regulation of Profilin-2 by microRNAs and RNA-binding proteins forms a critical regulatory node for...

by Carolyn Sangokoya, Isabella R. Rosso, Rana Ghandehari-Alavijeh, Robert Blelloch Post-transcriptional control by RNA binding proteins (RBPs) and microRNAs play central roles in...

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journals.plos.org /1 day ago

Non-adaptive evolutionary forces predominantly shape nucleotide composition near human transcription start sites

by Yi Qiu, Emilie Hebraud, Fanny Pouyet, Alexander F. Palazzo In the human genome, mutation rates vary along genes, yet how their fine-scale structure contributes to gene evolutio...

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journals.plos.org /2 weeks ago

HiFIseek: Gene-specific enrichment of high-impact mutations in associated genomic regions

by Rafael Riudavets Puig, Denise G. O’Mahony, Ina Skaara Brorson, Ksenia Sokolova, Vessela N. Kristensen, Anthony Mathelier Transcription is regulated through the sequence-specifi...

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rna-seqblog.com /2 weeks ago

GP-DHT uses single-cell RNA sequencing to map gene regulatory networks

Single-cell RNA sequencing combined with GP-DHT helps predict transcription factor and target gene relationships, providing a...

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journals.plos.org /1 month ago

Tcf15 promotes an open nucleolar chromatin state to safeguard ribosome biogenesis and genome stability in mouse embryoni...

by Yu-ping Dong, Yi-Min Chen, Min Tang, Hu Zhou, Lin Wang, Ping Zheng Embryonic stem cells (ESCs) exhibit a hyperactive chromatin state at ribosomal RNA (rRNA) genes, which not on...

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bioengineer.org /1 month ago

Improved spike-in normalization reveals how active histone modifications relate to transcription

Chromatin, the molecular packaging system that compacts DNA inside the nucleus, is not merely a passive storage device. By loosening or tightening access to genetic material, it he...

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rna-seqblog.com /4 weeks ago

Single-cell TimeLapse-seq reveals MTA is an essential retrotransposon

Very early in development, an embryo must begin using its own genome instead of relying only on RNA and proteins inherited from the egg. This transition is known as zygotic genome...

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journals.plos.org /1 week ago

The AF-2 domain of estrogen-related receptor interacts with PPRC1 to modulate larval epidermal marking in Bombyx mori

by Jinxin Wu, Die Liu, Haoran Xu, Lingqing Zeng, Ping Lin, Ping Zhao, Guanwang Shen Estrogen-related receptors (ERRs) have no natural ligands, vertebrate ERRs rely on their activa...

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journals.plos.org /2 weeks ago

DeCTCF: Decoding CTCF binding sequences by leveraging predicted epigenomic features

by Lu Chai, Jie Gao, Tinghe Guo, Teer Ba, Zihan Li, Junjie Liu, Yong Wang, Lirong Zhang CTCF is a key architectural protein with diverse roles in genome organization and gene regu...

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