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RNA sequencing and spatial transcriptomics were combined to benchmark leading platforms, helping researchers compare how accurately each maps gene activity within complex tissues.....
Atlases like this one can provide the labeled, cell-type-resolved training data that artificial intelligence models need to make accurate predictions—a bottleneck that has historic...
A new spatial transcriptomics framework compares tumor “floor plans." In a study of 262 solid tumors, the team identified recurring spatial groups that may connect spatial structur...
RNA sequencing combined with tissue expansion enabled ultra-high-resolution spatial transcriptomics, allowing researchers to map gene activity within individual cells with...
Spatial biology has transformed the way researchers view tissues, revealing that cells are defined not only by their molecular identities but also by their precise locations and in...
ARCADIA integrates single-cell RNA sequencing with spatial proteomics to reveal how tissue neighborhoods influence B-cell maturation, T-cell activation, and other transcriptional p...
Using single-cell multiomics, spatial transcriptomics, and an AI model called Hicformer, the team generated a multiscale view connecting genome structure, gene regulation, and tiss...
Spatial RNA sequencing maps RNA synthesis and degradation across the mouse brain, revealing how different regions rapidly adjust gene expression in response to stimulation...
Image-based spatial transcriptomics was applied to longitudinal human endomyocardial biopsy samples from 62 adult and pediatric heart transplant recipients during and after histolo...
Cancer’s genetic chaos may soon be readable in the ordinary stained images pathologists already examine under a microscope. A new study published in Nature Biomedical Engineering i...
A new single-cell technology is giving researchers an unusually complete view of how individual cells establish and change their identities. Called OneCell CUT&Tag, the method...
STGBench generates realistic paired DNA and RNA sequencing datasets with known genetic alterations, enabling accurate benchmarking of spatial genomics and transcriptomics analysis....
The team integrated high-resolution spatial transcriptomics, single-cell RNA sequencing, and chromatin-accessibility profiling across nine sequential stages of lung colonization in...
RNA sequencing combined with spatial genotyping mapped where neoantigen-specific T cells interact with tumor cells, revealing organized immune niches that may guide personalized ca...
by Xiang Chen, Zihan Yang, Xiaoyu Liu, Zhiyi Xie, Wenlu Guo Paired single-cell multi-omics technologies provide direct within-cell correspondence across molecular layers and offer...
by Shuzhen Ding, Zhou Yu, Jingsi Ming The rapid advancement of spatial transcriptomics has substantially improved our understanding of the spatial architecture and gene expression...
Spatial omics can tell us exactly where and when genes switch on inside a plant or individual—illuminating crucial details of processes such as wheat breeding. A global consortium...
SPIDER uses single-cell RNA sequencing references to reduce noise in spatial transcriptomics, improving gene expression patterns, tissue structure identification...
A genome-scale CRISPRi atlas maps transcriptional consequences for 11,692 gene perturbations across more than 2.5 million human iPSCs. The resource reveals regulators of metabolism...
RNA sequencing benchmark compares long-read bioinformatics tools for single-cell and spatial transcriptomics, helping researchers improve isoform detection and gene...
Unlike prediction-based approaches, Broken String Biosciences says BaseMap ABE generates genome-wide data directly from biologically relevant cells, providing researchers with clea...
Researchers generated a single-cell atlas of the striatum, identifying 31 neuronal subpopulations and disease-linked vulnerabilities that could inform studies of Huntington’s disea...
HeartBeat.bio and Cubase Bio are combining cardiac organoids with 3D spatial transcriptomics and RNA sequencing to study...
A new study shows that 3D genome architecture is altered in prefrontal cortex cells of individuals with Alzheimer's disease.
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