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Scientists unveiled a reaction that swaps key carbon groups in complex compounds, offering a faster route to test new medicine candidates.
A new method screens large libraries of synthetic cyclic peptides to identify compounds that can enter cells for therapeutic effect, opening avenues for a modality that combines th...
A slow-switching molecular cage reveals how chemical signals trigger gradual structural changes, offering design clues for molecular machines and smart materials.
As synthetic oligonucleotide therapeutics become validated and feasible for commercial production, manufacturers are being urged to become familiar with the Chemistry, Manufacturin...
Macrocycles, de novo antibodies, and mRNA therapies are expanding the drug discovery toolbox for unmet patient needs. The post Novel Therapeutic Modalities Target the Undruggable a...
New AI‑designed miniproteins precisely modulate GPCR signaling and reveal a new "receptor diversion" microscopy-based screening system for targeting receptors long considered diffi...
Behind the expansion of their collaboration, Incyte and Genesis say, is the promise shown so far by the two initial targets, both selected by Incyte as called for in the initial st...
In biological systems, proteins communicate by locking onto specific molecular partners with high precision. For decades, scientists have tried to replicate this selectivity using...
Light-switchable molecules could tune spin-wave filters in 2D magnets, offering a chemical route to reprogrammable nanoscale magnetic circuits.
Researchers have developed a type of peptides that can enter cells and block protein interactions considered difficult to target with drugs.
Researchers use a Vitamin E-derived molecule to enhance the ability of DNA-based nanostructures for drug delivery, imaging, and therapeutics.
In the quest for faster and more efficient drug discovery, researchers have uncovered a novel method to enhance molecular complexity using a surprisingly straightforward tool: blue...
A nanopore detection method can rapidly identify individual proteins, aiding disease research, drug development, and biomarker discovery.
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