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rna-seqblog.com /1 month ago

Avoiding a sticky situation: how cells stop messenger RNAs from clumping together

RNA sequencing reveals how naturally occurring mRNA sequences may reduce harmful RNA aggregation, offering insights into transcriptome stability and the design of mRNA therapeutics...

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biopharmadive.com /1 week ago

Experimental Arrowhead RNAi drug hints at Alzheimer’s benefit

In a first, a subcutaneously administered RNA interference medicine crossed into the brain and plummeted levels of a protein implicated in the disease.

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biopharmadive.com /6 days ago

Next-gen RNAi drugmaker City prices $200M IPO

The offering will support a trio of medicines in or nearing clinical testing, as well as earlier research into RNAi treatments that get into tissues outside the liver.

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biopharmadive.com /4 weeks ago

RNAi drug specialist ADARx raises $446M IPO

ADARx is the only maker of RNA-based drugs to go public since 2024 and the first RNAi biotech to price an IPO in the U.S. in more than a decade.

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rna-seqblog.com /4 weeks ago

RNA variant imaging for cancer diagnosis

RNA Variant Imaging is attracting attention because it addresses a persistent blind spot in cancer diagnostics: many clinically relevant RNA isoforms, splice events, and fusion tra...

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genengnews.com /1 month ago

RNAV8 Bio Joins ARPA-H Team to Pioneer Programmable RNA Medicines

The PROPEL program aims to control gene expression through RNA structure, building logic-gated RNA therapies that switch on only where and when intended, without altering the genom...

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biopharmadive.com /3 days ago

Merck KGaA bets on RNAi with $1.3B Silence buyout

The acquisition gives the German company a promising blood disorder medicine that passed a Phase 2 test and could threaten a Takeda drug.

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medcitynews.com /6 days ago

City Therapeutics’ Upsized IPO Raises $200M to Bring RNAi Drugs Beyond the Liver

City Therapeutics’ lead RNA interference therapy could become an alternative to blockbuster-selling anticoagulants. The company’s technology for designing RNAi drugs and delivering...

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scitechdaily.com /3 weeks ago

A New RNA Strategy Could Target Thousands of Genetic Disorders

This new approach targets disorders including cystic fibrosis, muscular dystrophy, and some cancers. In lab-grown tissue from a cystic fibrosis patient who did not respond to exist...

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medcitynews.com /3 weeks ago

Gene Silencing-Biotech ADARx Makes Some Noise With $535M Stock Market Debut

ADARx Pharmaceuticals upsized its IPO and raised additional cash through a private placement with partner AbbVie. Lead ADARx program onvuzosiran is in Phase 3 testing for the rare...

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rna-seqblog.com /1 month ago

Small RNA sequencing reveals regulatory roles for sdRNAs in acute myeloid leukemia

Small RNA sequencing reveals cell-specific sdRNA patterns in AML and healthy hematopoiesis, linking certain snoRNA-derived RNAs to gene regulation and poorer patient outcomes...

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rna-seqblog.com /4 weeks ago

Villanova biology professor awarded NIH grant to advance understanding of RNA decay

RNA sequencing will help Villanova researchers investigate how UPF1 controls nonsense-mediated RNA decay and how cells identify defective RNAs linked to genetic disease...

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rna-seqblog.com /2 weeks ago

Boehringer taps Envisagenics’ AI to mine RNA splicing for cancer targets

RNA sequencing and AI help identify tumor-specific alternative splicing events that may reveal new precision oncology targets across solid tumors...

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rna-seqblog.com /3 weeks ago

The Human RNome Project Consortium seeks to publish first-ever complete sequence of the bodyÐ²Ð‚â„¢s RNA

RNA sequencing efforts from the Human RNome Project aim to build a comprehensive reference of human RNA sequences, isoforms, processing states and chemical modifications...

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genengnews.com /1 month ago

Moonwalk to Use $70 Million to Develop RNAi Therapies for Obesity, Cardiometabolic Disease

New financing will help Moonwalk Biosciences expand its pipeline of siRNA medicines targeting adipose tissue while building out its proprietary drug discovery platform. The post Mo...

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rna-seqblog.com /1 month ago

RNA sequencing reveals functional chimeric mRNAs in mammalian immunity

Direct RNA sequencing revealed thousands of chimeric mRNAs in mammalian cells, uncovering previously unknown proteins with roles in immunity, inflammation, and potential drug disco...

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