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rna-seqblog.com /1 month ago

MSK scientists uncover RNA’s hidden role as protein chaperone

RNA sequencing continues to reveal unexpected RNA functions, including how mRNA 3′UTRs help regulatory proteins fold correctly and maintain proper cellular activity... The post MSK...

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bioengineer.org /1 month ago

How Chaperones Build RNA Silencing Complexes

In a groundbreaking revelation that promises to reshape our understanding of gene regulation, scientists have decrypted the elusive structural dynamics of the RNA-induced silencing...

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fightaging.org /1 month ago

Products of Transfer RNA Cleavage are Essential for Stress Response Slowing of Aging

Biochemistry is enormously complex. The closer that researchers look, the more that they will find. Details remain incompletely mapped and understood at every level; there are only...

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rna-seqblog.com /3 days ago

Researchers show how early RNA-based life may have repaired its genome, providing insight into the origins of life

A newly engineered ribozyme repairs broken RNA, creating new opportunities for studying RNA evolution while improving the detection of damaged molecules through RNA sequencing...

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journals.plos.org /1 month ago

The <i>Pseudomonas aeruginosa</i> ribonuclease Ribocin cleaves eukaryotic ribosomes at helix 69 to inhibit h...

by Alejandro Vasquez-Rifo, Denis Susorov, Emily H. Sholi, Gabriel Demo, Yasaman Jami, Jihui Sha, James A. Wohlschlegel, Andrei Korostelev, Victor Ambros Pseudomonas aeruginosa emp...

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phys.org /3 days ago

RNA-only repair enzyme reveals how primordial life could have protected genomes

In most modern cells, DNA stores the genetic blueprint, and proteins replicate, repair and build from those blueprints. At the same time, proteins require instructions from DNA to...

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genengnews.com /1 month ago

mRNA Tails Play Key Role in Folding Regulatory Proteins

While 3' UTRs have traditionally been dismissed as key regulators, a new study shows that these highly conserved mRNA tails facilitate the folding of intrinsically disordered prote...

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lifespan.io /2 weeks ago

How a Primate-Specific RNA Strand Worsens Senescence

Researchers have discovered a primate-specific piece of non-coding RNA that is linked to aging and makes senescence worse. The packing matters While non-coding RNA strands (ncRNAs)...

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journals.plos.org /1 month ago

The regulation of Xrp1 expression by uORFs and main ORF sequences and its function in <i>Drosophila</i> dise...

by Hidetaka Katow, Thao Nguyen, Sarah Hyunsoh Park, Hyung Don Ryoo The Integrated Stress Response (ISR) mediates cellular adaptation to endoplasmic reticulum (ER) stress, amino ac...

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rna-seqblog.com /3 weeks ago

New approach reveals how complete riboswitches control gene expression

RNA sequencing combined with high-throughput functional profiling enabled researchers to build complete riboswitch models and uncover coordinated structural changes involved in gen...

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