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A new study introduces "apical hypercontextualisation," explaining how psychedelics target serotonin receptors on layer V pyramidal neurons to shift brain processing from raw senso...
August 13, 2026 | Source: Nautilus | by Kristen French Mescaline, derived from cacti like peyote in North America and San Pedro in South America, is the drug that gave psychedelic...
There’s a lot of it about and most dangerous when practised by billionaires… Sam Woolfe writes…. Being passionate and enthusiastic about psychedelics – or even evangelical about th...
As potential approvals of psychedelic therapies draw closer, attention is increasingly turning to what their real-world delivery might look like. While many details remain unknown,...
As psychedelic therapies expand, new clinics treat uncommon long-term harms
This morning, Definium Therapeutics announced positive topline results from its Phase 3 study of LSD (DT120) for generalised anxiety disorder (GAD). It comes just two months after...
How psychedelics can help us feel at one with existence.ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story, subscribe h...
Results from a late-stage study focused on generalized anxiety disorder were a “clean win” to analysts, who believe Definium has a drug with multibillion-dollar sales potential.
Psychedelics are often associated with disconnecting from reality, but a recent neuroimaging study found that psilocybin can actually make our brain activity more connected to the...
Psychedelics can create a new “hidden order” in brain activity that could explain how these drugs alter our sense of self
"A plausible mechanism for altered bodily awareness and perception."ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story,...
A psychedelic experience can crack your world wide open. But the window closes fast, and what you do while it's open decides whether anything actually lasts.
Kimon de Greef's The Ego Trip chronicles the rise of a potent psychedelic drug, from the toads that secrete it to the man who claimed it has amazing powers. Olivia Goldhill discove...
The Sonoran Desert toad is the only animal known to make a psychedelic. Its glands secrete 5-MeO-DMT, the compound users call the God molecule. The toad exists only in Sonora, Mexi...
As public perception and legislation moves, psychedelic drugs could become accepted treatment for people battling a range of mental health disorders.
SAMHSA Convenes Experts to Tackle Psychedelic Data Gaps Dozens of experts met in D.C. last week under the auspices of SAMHSA’s two-day consultation, titled ‘Addressing Data Gaps to...
We’ve been waiting on this one for three years. If you’ve frequented this blog, you know three years is basically an eternity in Food and Drug Administration (FDA) years but a blin...
Earlier this month, we covered Definium Therapeutics’ second Phase 3 readout, this time pertaining to its first LSD (DT120) for generalised anxiety disorder (GAD) study. (See Smoot...
Ibogaine joins a growing list of psychedelic drugs that have been found to potentially have beneficial effects on brain health and mood.
Psychedelics are inherently chaotic drugs, dissolving the boundary between self and surrounds by sowing discord in the brain.Continue ReadingCategory:
Dimethyltryptamine (DMT) is getting lots of media attention. Is it the key to unlocking the secrets of reality, or just a popular means for escaping this one?
There’s a whole book to be written here. Thankyou Chronicles of Kykeon The history of psychedelics, as it’s usually told, is a story about men. Who hasn’t heard of Albert Hofmann...
How the conservative activist Bryan Hubbard, with help from Rick Perry and Joe Rogan, persuaded Trump and the G.O.P. to embrace ibogaine, a psychedelic drug derived from an African...
In June 2023, FDA issued the first draft guidance on clinical investigations involving psychedelics. The 11-page document offered pointers on everything from nonclinical research a...
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