Social Media Ideas for Pan-Cancer Analysis

Integrated multi-omics analysis reveals the molecular landscape and therapeutic strategies in Chinese cervical cancer pa...

by Tao Pan, Xucui Zhuang, Ya Zhang, Jiyu Guo, Si Li, Can Zhang, Lili Han, Fuxia Li, Yueying Gao, Jinyang Yu, Yongsheng Li, Chaoyang Sun Genomic or transcriptomic sequencing guides...

Identifying shared polygenic risk across cancers

by Jiaqi Hu, Maiyier Muheyati, Leqi Xu, Andrew DeWan, Hongyu Zhao Background Shared genetic susceptibility across cancers has been reported but is generally modest at the genome-wi...

Multi-omics analysis of high-grade serous ovarian cancers reveals heterogeneity and distinct immunological patterns base...

by Jing Qian, Rania Bassiouni, Yuxin Jin, Seeta Rajpara, Monica Neuman, Varun U. Khetan, Bodour Salhia, David W. Craig, Joseph W. Carlson, Lynda D. Roman, John D. Carpten High-gra...

Biomarker discovery and patient stratification in pancreatic cancer using incomplete multi-omics data

by Alejandra Paja-García, Rafael Romero-Becerra, Tero Aittokallio, Alberto López Pancreatic ductal adenocarcinoma (PDAC), with a 12% 5-year survival rate, is the most aggressive t...

Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenet...

by Luisa Quesada Camacho, Mohammad Fallahi-Sichani Epigenetic dysregulation is a common feature of cancer. It creates vulnerabilities arising from an increased reliance on chromat...

Interpretable neural networks prioritize cancer driver genes from genome-wide dependency landscapes

by Qingyang Yin, Liang Chen Identifying cancer driver genes and their therapeutic impact remains a core challenge in computational cancer biology. We introduce xNNDriver and xAEDr...

Single-cell RNA sequencing links genetic mutations to cell behavior in cancer

Single-cell RNA sequencing links somatic mutations with cell states, helping researchers trace clonal evolution and identify phenotypes associated with cancer progression and treat...

Non-coding RNA 7SK drives tumor resistance by coupling local oncogenic activation with global transcriptional repression

by Ping Xu, Zile Luo, Xi Chen, Zhongyang Yuan, Le Cheng, Yi Yang, Hongcheng Lin, Qiong Zhang, Pengfei Qin The conserved non-coding RNA 7SK is a well-established global transcripti...

GPSM2 Drives Pancreatic Cancer via m6A-Modified YAP1 mRNA

Pancreatic cancer has long been one of medicine’s most stubborn adversaries, a disease so aggressive and so difficult to detect in its early stages that it is often described as th...

Metarrestin’s Anti-Cancer Mechanism Mapped Through Network Pharmacology

A new network pharmacology study maps how the anti-metastatic drug metarrestin rewires cancer cell protein networks and identifies the cell-cycle regulator CDKN1B as its highest-af...

FDA panel supports multicancer early detection test

An FDA advisory panel expressed support for a blood test designed to detect early signs of multiple cancers, including some for which no screening alternative exists.Members of the...

Cancer leads AI physician queries across 9 countries

While cancer continues to be a major global health challenge, it is also a rapidly changing area of medicine. Targeted therapies, immunotherapy, genomic testing, biomarker-driven t...

Computational deconvolution of drug sensitivity via single-cell–to–bulk transcriptome mapping

by Alexandre Coudray, Romain Forey, Benjamin Bejar Haro, Filipe Martins, Joana Carlevaro-Fita, Shaoline Sheppard, Sandra Eloise Offner, Gioele La Manno, Guillaume Obozinski, Didier...

Cell Death Genes Could Predict Survival in Esophageal Cancer, Study Finds

Researchers built a five-gene PANoptosis-based risk model and nomogram that predict survival, immune landscape, and treatment sensitivity in esophageal cancer patients.

Genome analysis uncovers candidate genes for hereditary breast and ovarian cancer

By: Inka Burow, Hannover Medical School From: medicalxpress.com Breast cancer is the most common form of cancer among women in Germany: Around 1 in 8 women will develop it during t...

p53 expression patterns link KAISO and field cancerization in oral cancer

When the Guardian Loses Its Partner: p53 Surges While KAISO Collapses in Oral Cancer Tissue Deep in the lining of the mouth, one of biology’s most celebrated molecular alliances ap...

Incyte: Digesting The ESMO Updates In Pancreatic, Colorectal, And Ovarian Cancer

AI-Guided Modeling Uncovers Hidden Switches That Could Heat Up Cold Pancreatic Tumors

Pancreatic ductal adenocarcinoma remains one of the deadliest cancers in the world, and one of the hardest to treat with immunotherapy. The reason lies in its notorious reputation...

Genome-Wide DNA methylation profiling of tissue-plasma pairs identifies Novel cfDNA biomarkers for the diagnosis of gast...

by Hailing Ou, Jinli Miao, Fusheng Ling, Jie Gao, Tingan Wang, Zhihua Ye, Chunbo Zhang, Mingwei Huang, Yuzhou Qin Screening for gastric cancer (GC) is critical for improving patie...

Functional genomics maps broad, convergent asciminib resistance mechanisms in BCR::ABL1

A sweeping genetic map of drug resistance in chronic myeloid leukemia has revealed that cancer cells can evade asciminib through mutations scattered across much more of the BCR::AB...

Hyper-mutational processes provide a head-start for weak cancer drivers: Explaining atypical <i>KRAS</i> var...

by Michael D. Nicholson, Ian Tomlinson Hypermutant cancers frequently contain atypical driver gene variants, which may provide sub-optimal oncogenic advantages. The reason why wea...

US regulators back multi-cancer blood test – but Hong Kong doctors remain cautious

Efforts to detect multiple cancers through a single blood draw are gathering momentum after US regulators endorsed the technology for the first time, although experts say wider ado...

Grail multicancer detection test wins FDA advisers’ backing

Panel members said the first-of-a-kind blood test should not be used to replace medical guideline-recommended cancer screenings, however.

From Discovery to Remission: How Agentic AI Is Reshaping the Oncology Continuum

Agentic AI is closing oncology's data gaps — from drug discovery to survivorship. See how AI agents in healthcare are reshaping cancer care today.