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Researchers have pinpointed the brain's "placebo circuit." By training the brain to release its own endorphins in the vlPAG region, they achieved broad-spectrum pain relief without...
In a groundbreaking advance that could reshape the future of pain management, researchers led by Clarke, Mugglestone, and Lojkiewiez have demonstrated the capacity of multi-focal u...
By pinpointing the neural circuits and peptides behind placebo pain relief, scientists showed effects that span pain types, highlighting possible treatment approaches that could av...
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In “failing” this study delivered an important pain management insight for total hip arthroplasty surgeons…
A new study demonstrates that tracking high-speed facial micromovement spikes provides an objective, quantifiable metric for human discomfort.
Summary: Researchers mapped the precise brain pathway that drives the nocebo effect, the biological phenomenon where negative expectations actively amplify physical pain. The resea...
Researchers have engineered a novel nitazene-based opioid, DFNZ, that provides potent pain relief without causing respiratory depression or addiction. The "superagonist" drug could...
A single dose of psilocybin provides up to a month of nerve pain relief and fundamentally supercharges the efficacy of traditional painkillers.
By Chris SeenanIn a 2026 study I conducted with colleagues on people with peripheral arterial disease, one participant described how leg pain had disrupted his golf for years. It f...
By Pat AnsonThe same academic institution that helped launch a nationwide crackdown on opioid medication has a new suggestion on how to treat chronic pain: hypnosis.Researchers at...
By Pat Anson A new study has found what many chronic pain patients have already learned the hard way: It’s difficult to get a diagnosis.Researchers at The University of Texas at Ar...
RNA sequencing of human neck nerve tissue suggests chronic pain may arise from inflammation in cells surrounding pain-sensing neurons, rather than neurons alone. The findings point...
By Pat AnsonMany chronic pain sufferers bristle at the notion that pain is “all in their head” or that it has psychological origins.They’re not going to like some recent headlines...
Neuroscientists have identified a dedicated brain circuit responsible for chronic pain. By silencing this loop, researchers were able to end pain hypersensitivity in mice without a...
Understanding pain through a biopsychosocial framework is essential for effective, patient-centered care. Among osteopaths, misconceptions about pain mechanisms may hinder appropri...
A study of 1,000 Japanese patients reveals that undiagnosed ADHD traits may be a hidden driver behind treatment-resistant chronic pain.
A hidden process in the brain may quietly decide whether long-term pain results in resilience or depression. Scientists have identified a brain process that may explain why chronic...
Run by medical specialists, the program combines cognitive behavioral therapy with additional beneficial activities The post To Reduce Chronic Pain, a New Digital Program Could Hel...
WEDNESDAY, April 29, 2026 — U.K. resident Fiona McNiven can tell you how chronic pain can wear a person down, as she spent more than three decades battling muscle and neuropathic p...
In a groundbreaking study published in Nature Communications on April 1, 2026, researchers from VIB, VUB, and KU Leuven have unveiled an intricate molecular mechanism governing the...
Opioids are often used to control pain following total knee arthroplasty (TKA). Opioid-sparing pain relief tools are needed in the current setting of the opioid crisis. This prospe...
The search for a safer opioid has followed pain medicine for decades. Doctors still need strong drugs for surgery, major injury, cancer pain, and severe flare-ups. Yet the same med...
By Dr. Lynn WebsterIn Greek mythology, the goddess Panacea carried a potion that could heal any disease. It’s a seductive image, and it’s how GLP-1 drugs can start to feel as repor...
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