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by Joe G. Greener Structural bioinformatics aims to answer biological questions by considering biomolecular structures at scale. We now have accurate predictions and need to ask w...
Scientists record the stepping motion of RNA polymerase along DNA using long-lasting fluorescent DNA origami nanostructures that track life’s smallest movements.
A newly published study in Molecular Cell unravels the intricate structural dynamics of the protein SPOP, shedding light on how cancer-associated mutations disrupt its delicate fun...
A new molecular design strategy is bringing two traditionally separate worlds of chemistry together: proteins, nature’s highly evolved molecular machines, and foldamers, synthetic...
Researchers developed a customized experimental workflow combining cross-linking mass spectrometry with AlphaFold-based structural modeling and functional assays to directly map pr...
Long polymer chains are among the hidden structures that shape the modern world. They give plastics their strength, help biological materials organize themselves, and form the mole...
How do related proteins develop different functions? This is the question investigated by a research team involving Kiel University, DESY and the Center for Structural Systems Biol...
Atlases like this one can provide the labeled, cell-type-resolved training data that artificial intelligence models need to make accurate predictions—a bottleneck that has historic...
Nearly every cell in the human body contains essentially the same genetic information, yet different cells activate different genes. For regulatory proteins to reach these genes, D...
A study of worms finds a protein that helps shape the structure of the genome is critical for establishing the identity of some neurons.
Influenza A virus is infamous for its speed—yet the molecular choreography inside infected cells is still being uncovered. In a new study published in Nature Microbiology, research...
Topoisomerases are molecular machines that play a critical role in resolving DNA tangles and supercoiling generated during DNA replication. Source
The finding could eventually enable the use of DNA packaging in cells for disease diagnosis and treatment. In preserved cells, newly developed fluorescent probes allowed researcher...
A DNA origami nanosyringe introduces mechanically controlled molecular transport into synthetic cells. This opens new opportunities for synthetic biology, engineered biointerfaces...
Artificial foldamers bind proteins with high precision, enabling rings, networks and porous architectures that could serve as building blocks for new materials.
by Mingze Sun, Di Zhang, Zhiyuan Li, Yihan Lin N6-methyladenosine (m6A), the most abundant mRNA modification in eukaryotes, plays essential roles in gene regulation and disease pa...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
A new quantum sensing technique could enable measurements of single protein structures and other important molecules, with potential applications in drug discovery and structural b...
Because we are dealing with foundational scientific discoveries, we will address several “So what?” questions. Source
These are the same type of understandable and logical computation circuits that humans design. What can we learn from observing this similarity? Source
Primate color vision depends on three cone pigments that all bind the same chromophore, 11-cis-retinal. Yet small differences in the surrounding protein tune each pigment to differ...
by Irene Gallina, Sara N. Richter Alternative DNA secondary structures known as G-quadruplexes (G4s) form across all kingdoms of life, regulating transcription, telomere stability...
by Sarah M. Groves, Min-Jhe Lu, Astrid Catalina Alvarez-Yela, Monserrat Gerardo-Ramírez, P. Todd Stukenberg, John S. Lowengrub, Kevin A. Janes Biomolecular condensates create dyna...
A new study has found that the signals cells use to switch genes on have remained almost unchanged across two billion years of evolution, but the ones used to switch genes off vary...
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