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Progression independent of relapse (clinical & Imaging) drives disability and is the basis for progression of disability. Natalizumab has its main action outside of the brain s...
Signori A, Montobbio N, Bovis F, Ponzano M, Schiavetti I, Krenn A, Sormani MP. Uncoupling Relapse Reduction and Disability Progression: Evidence From Tolebrutinib Studies. Neurol C...
FRIDAY, May 29, 2026 — An already-approved MS drug can significantly slow progression in people with primary progressive multiple sclerosis (PPMS), according to a new study.Patien...
FRIDAY, May 29, 2026 — An already-approved MS drug can significantly slow progression in people with primary progressive multiple sclerosis (PPMS), according to a new study. Patien...
In stable relapsing-remitting multiple sclerosis (RRMS), higher physical disability scores and brain volume loss on MRI are stronger indicators of cognitive impairment than common...
In a groundbreaking shift in understanding multiple sclerosis (MS), researchers from the Magnetic Resonance Imaging in MS (MAGNIMS) consortium have unveiled a transformative approa...
Ocrevus (ocrelizumab) delayed disability progression and worsening hand function among a large group of people with primary progressive multiple sclerosis (PPMS), including those w...
Why do some multiple sclerosis patients deteriorate rapidly while others experience mild symptoms for decades? A post-mortem neuro-audit reveals that severe MS progression is linke...
Comorbidities may exacerbate disease burden in people with Multiple Sclerosis (pwMS), yet their influence on disease progression and patient-reported outcomes (PROs) remains poorly...
Having a second autoimmune disease does not accelerate disability progression in people with multiple sclerosis (MS), according to a large single-center study. Among 1,230 MS patie...
Awareness initiatives have played an important role in reshaping how multiple sclerosis (MS) is perceived. Over the past several decades, MS has evolved in the public and scientifi...
The understanding and management of neuropsychiatric symptoms such as depression and cognitive difficulties in multiple sclerosis (MS) have advanced substantially, but there’s more...
If you are living with secondary progressive multiple sclerosis (SPMS), you know that life feels different from how it used to be. For years, you might have lived in the RRMS world...
No disrespect to the authours here, but when I read the title of the paper I asked what the flip does this mean? What is the Era of PIRA-A. This is an MDPI journal and so is a pay...
Someone has made a comment about the poor impact of treatments on progression and I made comment about trials and you only find lesions if you look for them. MRI can spot lesions i...
First-line treatment with Ocrevus (ocrelizumab) preserved walking abilities and hand function in most people with early relapsing-remitting multiple sclerosis (RRMS) over six years...
Tiziana Life Sciences‘ experimental nasal spray foralumab continues to show signs that it may help slow disability progression and ease fatigue in people with nonactive secondary p...
This is a phrase I heard someone say when they were describing an MS Drug…I tend to think this when I hear the word PIRA…There is worsening in MS but is it independent of relapse b...
The presence of multiple asymptomatic spinal cord lesions — areas of damage, as captured by imaging scans — is associated with about a twofold higher risk of developing multiple sc...
Lindsay Kelly shares how recognizing subtle symptoms and speaking up helped guide her husband’s progressive MS care. The post A caregiver’s role in recognizing progressive MS appea...
A new type of MRI scan may be able to distinguish active multiple sclerosis (MS) lesions from chronic lesions — without the need for injected contrast dye — while also offering clu...
Mapi Pharma’s long-acting formulation of glatiramer acetate, GA Depot, may help stabilize disability scores over time in people with both relapsing forms of multiple sclerosis (MS)...
Among people with relapsing forms of multiple sclerosis (MS) and highly active disease, Mavenclad (cladribine) treatment resulted in stable or better cognitive function over two ye...
I have been critical of neuros for using the escalating apporach to DMT and you us a higher efficacy drug after the failure of treatment. A strategy based on failure was always a f...
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