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New AI Method Ranks Metabolites by Their Impact on Graph Neural Network Predictions

Metabolomics, the large-scale study of small molecules in biological systems, has long faced a stubborn interpretability problem. Researchers can measure thousands of metabolites a...

Advanced Imaging Technique Reveals Immune Cell Metabolic States in Blood Samples

Researchers showed how optical metabolic imaging (OMI) can be used to characterize metabolic activity within immune cells from the peripheral blood of patients, which could potenti...

Multi-omics reveals metabolic regulation of petal color in Phalaenopsis

In a finding that is already rippling through the world of ornamental plant science, researchers in China have pieced together, gene by gene and pigment by pigment, the molecular m...

The Emerging Power of Mass Spectrometry in Oncology

Novel approaches are urgently needed to improve availability of diagnostic assays, and recent efforts have shifted toward uncovering the biological pathways and molecular profiles...

Multiomics in 2026 and Beyond

Multiomics analysis combines data from two or more omics layers—such as genomics, transcriptomics, proteomics, and epigenomics. However, published criticisms of multiomics approach...

The Multi-Attribute Method (MAM) as a Biologics Lifecycle Backbone

A more coherent approach: a peptide-mapping LC-HRMS (liquid chromatography-high resolution mass spectrometry) workflow that can identify and monitor multiple product quality attrib...

New Mass Spectrometry Assay Tracks 42 Obesity Biomarkers in a Single Blood Test

Obesity has become one of the most consequential public health challenges of the modern era, driving elevated risks of type 2 diabetes, cardiovascular disease, and a constellation...

<![CDATA[The Next Chapter in Metabolic Drug Development]]>

The Metabolic Moment: 3 big bets to watch in metabolic disease

Explore three big bets in metabolic disease: the race to challenge Lilly and Novo, a pill that mimics exercise, and a gene therapy for diabetes. The post The Metabolic Moment: 3 bi...

Proteomics Maps Eye-Infecting Acanthamoeba Mitochondria Across Oxygen Levels

A new catalog of 1,122 mitochondrial proteins reveals how Acanthamoeba adapts to oxygen loss—and may highlight possible targets for treating sight-threatening infections. The post...

How macrocyclic drugs are gaining momentum in the cardiometabolic disease space

Discover biotech and big pharma’s emerging interest in developing macrocyclic drugs for cardiometabolic diseases. The post How macrocyclic drugs are gaining momentum in the cardio...

Metabolite Fingerprint in Seminal Plasma Could Explain Hidden Male Infertility

Male infertility is responsible for roughly half of all infertility cases worldwide, yet the standard diagnostic tool, conventional semen analysis, leaves a striking proportion of...

Multi-omics reveals molecular basis of meat quality variation in Red cattle muscles

Why does a ribeye taste different from a rump even when both come from the same animal, raised on the same farm and slaughtered on the same day? A new multi-omics study of Pinglian...

Omics data discovery agents: Agent-supported retrieval, reanalysis, and synthesis of published omics data

by Alexandre Hutton, Jesse G. Meyer The biomedical literature contains a vast collection of omics studies, yet most published data remain functionally inaccessible for computation...

Raman+NIR Spectra Improves Glucose Soft Sensing

Combining Raman and NIR spectroscopy into a single framework creates a multi-modal soft-sensing option that is effective for fed-batch, online, and in-line glucose sensing, prepari...

Postmortem Metabolomics Reveals Agonal Death Processes in Opioid Overdoses and Hangings

A Chemical “Fingerprint” in Blood Could Help Forensic Experts Distinguish Opioid Deaths from Hangings When a person dies after an opioid overdose, the body may offer forensic inves...

Exercise is good for us—but why?

RNA sequencing and multi-omics profiling reveal how exercise alters gene expression, metabolism and epigenetic regulation across 22 tissues, identifying molecular signatures of exe...

Metabolic health – Your body’s interconnected network

Metabolic health is increasingly shaping conversations around modern wellness. Most people think good metabolism is all about managing body weight or blood sugar. However, beyond t...

AI Learns to Predict Patient Outcomes Even When Key Omics Data Are Missing

Precision medicine has long promised a future in which a patient’s treatment is tailored to the molecular signatures written into their genome, transcriptome, epigenome, proteome a...

Gut Metabolite Genes Could Predict Colorectal Cancer Survival and Immunotherapy Response

Researchers built a four-gene signature based on propionate metabolism that stratifies colorectal cancer patients by survival risk and links tumor metabolism to immune features and...

Short, Intense Exercise Elicits Beneficial Metabolic Changes

A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than...

Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling

by Jie Zhang, Qian Shan, Xin Wang, Meijiao Li, Yang Yang, Mei Duan, Ruofeng Tang, Junxiang Zhou, Fengyang Wang, Yuehui Shi, Kai Jiang, Chonglin Yang Mitochondria catabolize nutrie...

Model-Free, Pure Component Analysis Could Help Biopharma Cut Costs

Spectroscopic analysis techniques rely on empirical models that are time consuming and expensive to make. Biopharma companies could speed development and reduce costs using a model...

Why Some IVF Calves Grow Too Big: New Multi-Omics Study Offers Clues

A multi-omics study of Holstein calves born after in vitro embryo production links fetal overgrowth to prolonged gestation, altered lipid and hormone profiles, two candidate circul...