Social Media Ideas for Marc Gerstein

<![CDATA[The Mechanics of Analyzing Linked Data Sets]]>

Metal binding site alignment enables network-driven discovery of recurrent geometries across sequence-divergent proteins...

by Vetle Simensen, Eivind Almaas Metal-binding sites (MBSs) are critical determinants of protein stability and biological function, yet methods for comparing their local binding e...

Integrating chemical structures as treatments improves representations of microscopy images for morphological profiling

by Yemin Yu, Emre Hayir, Neil Tenenholtz, Lester Mackey, Ying Wei, David Alvarez-Melis, Ava P. Amini, Alex X. Lu Recent advances in self-supervised deep learning have improved our...

Thermo and Michael J. Fox Foundation Collaborate to Advance Proteomics-Enabled Parkinson’s Therapy

PPMI creates a large-scale proteomics resource designed to help researchers study Parkinson’s disease at the protein level and investigate biological signals associated with diseas...

Scientists Analyze 267 Receptors That Control Protein Fate in Rare Diseases

Cells constantly control the fate of their proteins. They remove proteins that are worn out or no longer needed, but can also alter their activity, localization, or interactions wi...

GeneInsight: Condensing gene set knowledge via language models

by Wee Loong Chin, Kevin Chen, Timo Lassmann Gene set analysis often returns extensive annotations from multiple sources, requiring manual effort to identify coherent biological t...

A genomic-led strategy to anticipate drug safety effects

by Brian R. Ferolito, Andrea R. V. R. Horimoto, Kai Gravel-Pucillo, Daniel J. Golden, Hesam Dashti, Claudia Giambartolomei, Danielle Rasooly, Rachael Matty, Liam Gaziano, Yakov Tse...

Functional genomics maps broad, convergent asciminib resistance mechanisms in BCR::ABL1

A sweeping genetic map of drug resistance in chronic myeloid leukemia has revealed that cancer cells can evade asciminib through mutations scattered across much more of the BCR::AB...

With $263M, LifeMine unearths a new drug for organ transplants

Led by serial biotech entrepreneur Greg Verdine, the startup mined fungi genomes to find a safer alternative to the drugs widely used to prevent the body from rejecting transplante...

PCIPG: A comprehensive framework for protein complex identification based on a probabilistic graphical model

by Yixiang Huang, Lei Yang, Jiudong Wang, Xinqi Gong Protein complexes are molecular machines that execute essential cellular functions, but their computational identification rem...

The Multi-Attribute Method (MAM) as a Biologics Lifecycle Backbone

A more coherent approach: a peptide-mapping LC-HRMS (liquid chromatography-high resolution mass spectrometry) workflow that can identify and monitor multiple product quality attrib...

Single-Cell Atlas Simultaneously Maps 3D Genome Architecture and DNA Methylation

Atlases like this one can provide the labeled, cell-type-resolved training data that artificial intelligence models need to make accurate predictions—a bottleneck that has historic...

Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenet...

by Luisa Quesada Camacho, Mohammad Fallahi-Sichani Epigenetic dysregulation is a common feature of cancer. It creates vulnerabilities arising from an increased reliance on chromat...

scGSI: Graph-guided self-supervised integration of paired single-cell multi-omics

by Xiang Chen, Zihan Yang, Xiaoyu Liu, Zhiyi Xie, Wenlu Guo Paired single-cell multi-omics technologies provide direct within-cell correspondence across molecular layers and offer...

Brun named director of Texas A&M AgriLife Genomics and Bioinformatics Service

Marcel Brun’s appointment provides strategic continuity as long-time director Charlie Johnson retires The post Brun named director of Texas A&M AgriLife Genomics and Bioinforma...