Latest updates for Intrinsically Disordered Regions

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Recent items include:

  • Analysis and design of disordered polypeptides with optimized sequence patterning properties
  • Active Matter: Newfound Order in “Disordered” Proteins
  • mRNA Tails Play Key Role in Folding Regulatory Proteins

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journals.plos.org /1 week ago

Analysis and design of disordered polypeptides with optimized sequence patterning properties

by Arjun Singh, Ali I. Ukperaj, Gabriel F. Porto, Gregory L. Dignon Intrinsically disordered proteins (IDPs) exhibit phase separation behavior that is closely linked to their degr...

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scienceandculture.com /2 weeks ago

Active Matter: Newfound Order in “Disordered” Proteins

Intrinsically disordered regions of proteins may not be functionless after all. They appear to be multi-functional. Source

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genengnews.com /1 month ago

mRNA Tails Play Key Role in Folding Regulatory Proteins

While 3' UTRs have traditionally been dismissed as key regulators, a new study shows that these highly conserved mRNA tails facilitate the folding of intrinsically disordered prote...

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journals.plos.org /1 month ago

A zero-parameter first-principles gate framework for full-length TP53 missense variant interpretation

by Masamichi Iizumi Missense variant interpretation often achieves useful predictive performance but remains mechanistically opaque, particularly in proteins that combine structur...

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journals.plos.org

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