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RNA sequencing combined with protein analysis enables detailed tracking of immune cell activity, revealing cytokine dynamics and improving understanding of cancer and immune respon...
RNA sequencing of blood samples may help predict immune response to chemoimmunotherapy and support more personalized treatment strategies for high-risk...
by Hannah Kockelbergh, Shelley C. Evans, Liam Brierley, Peter L. Green, Andrea L. Jorgensen, Elizabeth J. Soilleux, Anna Fowler Insights gained through interpretation of models tr...
CIPHER‑seq is a single‑cell method that measures RNA and proteins simultaneously, exposing gaps in cytokine signaling and reducing mitochondrial stress signatures to give a clearer...
Scientists profiling immune activity in blood and spinal cord samples from ALS patients found inflammation patterns tied to disease subtype, progression speed, and survival, highli...
RNA sequencing of newly synthesized transcripts reveals dynamic immune cell activation and gene regulation during infection, providing real-time insight into how immune responses a...
RNA sequencing combined with spatial transcriptomics reveals how immune cells reorganize within lung tumors, providing deeper insight into tumor microenvironment dynamics and poten...
In the evolving landscape of oncology, the surge of immune checkpoint inhibitors (ICIs) has marked a paradigm shift, especially among elderly cancer patients. As the global populat...
RNA sequencing and multi-omics profiling identified four molecular subtypes of high-risk bladder cancer, helping explain differences in immunotherapy response and recurrence risk.....
In a groundbreaking advancement at the intersection of artificial intelligence and oncology, researchers have unveiled a pioneering method that harnesses machine learning to accele...
In a groundbreaking study reshaping our understanding of immune interactions within the liver’s biliary system, Thomann, Hemmer, Agrawal, and colleagues have unveiled an unpreceden...
by Rachel Mac Cann, Dana Alalwan, Gurvin Saini, Alejandro Abner Garcia Leon, Neeltje A. Kootstra, Padraig McGettrick, Aoife G Cotter, Alan Winston, Peter Reiss, Caroline Sabin, Pat...
Background: The maintenance and progression of pregnancy rely on immune homeostasis at the maternal-fetal interface. However, pregnancy complicated by autoimmune abnormalities can...
In the absence of specialized immune cells, the nematode Caenorhabditis elegans has evolved an extraordinary network of cross-tissue signalling circuits to defend itself against pa...
Pancreatic Ductal Adenocarcinoma (PDAC) metastasizes early and frequently to the liver, limiting therapeutic options and resulting in poor prognosis. Neutrophils are key immune pla...
RNA sequencing reveals inflammatory monocytes driving vascular damage in dermatomyositis, identifying JAK1 inhibition as a potential therapeutic strategy and clarifying differences...
Nanoscale Horiz., 2026, Accepted ManuscriptDOI: 10.1039/D6NH00215C, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported L...
by Yu Min, Ge Song, Lianlian Yang, Ling He, Shihong Xu, Kun Gao, Zheran Liu, Xingchen Peng, Lei Dai Head and neck squamous cell carcinoma (HNSCC) frequently resists PD-1 blockade...
by Pascal Lukas, Aurélien Gibeaud, Clarisse Schumer, Jonas Arruda, Jeremie Guedj, Olivier Terrier, Frederik Graw Understanding the mechanisms that govern viral spread in human air...
Path-IO accurately stratified immunotherapy outcomes for patients with metastatic non-small cell lung cancer (NSCLC). The model is validated across international real-world cohorts...
In the relentless pursuit to conquer sepsis—a life-threatening systemic inflammatory response triggered by infection—researchers have unveiled groundbreaking insights into the role...
RNA sequencing using TGIRT technology reveals blood-based RNA biomarkers that may improve diagnosis and monitoring of inflammatory breast cancer through liquid biopsy...
by Xabier Rey Barreiro, Jose Faro, Alejandro F. Villaverde T-cell receptor (TCR)-mediated T-cell activation is a key process in adaptive immune responses. The complexity of this p...
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