Search results for Hsc Aging

Researchers discover how stress signals weaken the aging immune system

As we age, our ability to maintain healthy blood and a strong immune system gradually declines, largely because hematopoietic stem cells (HSCs), the cells responsible for producing...

Scientists Uncover Hidden Trigger Behind Stem Cell Aging

A known cell-death protein turns out to quietly reshape stem cell aging. As people grow older, the body’s ability to maintain healthy blood and a strong immune system gradually wea...

Evidence for MLKL to be Important in Hematopoietic Stem Cell Aging

Researchers here identify a common mechanism in the cellular responses to various forms of stress that appears to drive aspects of hematopoietic stem cell aging via impairment of m...

Cell Death Protein Silently Ages Your Blood

Researchers have discovered that the "cell death" protein MLKL actually causes blood stem cells to age by damaging their mitochondria. Deactivating this pathway could lead to new t...

Scientists make old blood stem cells young again in major anti-aging breakthrough

As blood stem cells age, their lysosomes become overactive and damaged, triggering inflammation and weakening the body’s ability to regenerate healthy blood and immune cells. By ca...

Is Chronic Kidney Disease Accelerated Kidney Aging?

Chronic kidney disease is largely age-related, though can occur in younger people under some circumstances. It is one of a number of conditions in which research strongly implicate...

Aging

The Senescence Associated Secretory Phenotype as a Basis for an Aging Clock

The burden of lingering senescent cells grows with age in tissues throughout the body. Cells enter the senescent state constantly, but the pace of clearance of senescent cells by t...

Granzyme K Secreted by Aged T Cells Contributes to Cognitive Decline, an Effect that Can Be Reversed

The aging of the adaptive immune system, made up of B cells and T cells, is a complex process. Broadly, the pace at which new adaptive immune cells are created declines to a tiny f...

Why Fast-Cycling Skin Cells Decrease With Age

In Aging Cell, researchers have described how one dermal protein is related to maintaining the populations of fast-cycling skin cells and preserving skin integrity. […]

HuR Inhibition in Platelets Attenuates Degenerative Aging in Mice

Platelets play a vital role in blood clotting. A population of hematopoietic cells known as megakaryocytes spawn platelets by pinching off parts of their membrane and cytosol, form...

From germline immortality to somatic rejuvenation: Unlocking the ovarian blueprint for longevity

by Priscila Chiavellini, Vittorio Sebastiano Aging is typically framed as a one-way, irreversible accumulation of molecular damage in cells and tissues, leading to progressive fun...

Reversing Some Age-Related Changes via Creation of DNA Gaps with the Box A Domain of HMGB1

Control over the structure of nuclear DNA is critical to both gene expression and interactions between DNA damage and DNA repair systems. Most of us are by now at least passingly f...

High Altitude Populations Exhibit Features of Accelerated Immune Aging

You may recall the epidemiological study indicating that populations at moderate altitude exhibit better long term health and a lower risk of age-related disease. The authors of th...

Cutting-Edge Genomic Techniques Reveal Unexpected Cellular Changes in the Aging Brain

Aging is a complex and multifaceted process marked by gradual biological transformations that affect virtually all cells within the body. Despite decades of research, much about ho...

Aging is Soon to Be a Preventable Disease

For most of human history, cellular aging was treated as biologically fixed, an inevitable accumulation of damage with no meaningful pathway to reversal. That assumption is no long...

Cellular Senescence and Mitochondrial Dysfunction and the Aging of the Vascular Endothelium

Dysfunction in the cells making up the inner lining of blood vessels, the vascular endothelium, is thought to be an important first step in the aging of the vasculature more genera...

Some Researchers Choose Replacement Over Repair in Aging

A perspective published in Aging Cell details the replacement-based approaches being investigated by several research organizations. Repair versus replacement This perspective begi...

This method to reverse cellular aging is about to be tested in humans

A burgeoning field is launching its first clinical trial to find out whether dialing back cell development can safely refresh aged tissues and organs

Unraveling hair aging: a molecular atlas of human hair follicle senescence drawn by single-cell and spatiotemporal seque...

RNA sequencing reveals cell-specific changes in hair follicle aging, identifying disrupted signaling and stem cell decline that contribute to hair loss and graying...

Age Associated B Cells Contribute to Autoimmunity

Age-associated B cells are a problematic subset of the B cell population of immune cells that emerges in later life. In recent years researchers have uncovered various ways in whic...

Senescent Macrophages are Important in Liver Aging and Liver Disease

Senescent cells accumulate with age, but not all senescent populations are equal. Evidence suggests that some types of senescent cell cause more harm than others, and the research...

Blood as the Mirror of Aging

The blood industry is enormous, a long-standing component of the medical industry and one of the largest areas of focus for regulators. Blood is donated and sold in immense amounts...

A “death” protein may be the key to slowing aging at its source

Scientists have discovered that a protein linked to cell death is secretly driving the aging of blood stem cells in a completely different way. Instead of killing the cells, it dam...