Social Media Ideas for Gene Regulation

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journals.plos.org /1 month ago

Post-transcriptional regulation of Profilin-2 by microRNAs and RNA-binding proteins forms a critical regulatory node for...

by Carolyn Sangokoya, Isabella R. Rosso, Rana Ghandehari-Alavijeh, Robert Blelloch Post-transcriptional control by RNA binding proteins (RBPs) and microRNAs play central roles in...

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journals.plos.org /2 weeks ago

HiFIseek: Gene-specific enrichment of high-impact mutations in associated genomic regions

by Rafael Riudavets Puig, Denise G. O’Mahony, Ina Skaara Brorson, Ksenia Sokolova, Vessela N. Kristensen, Anthony Mathelier Transcription is regulated through the sequence-specifi...

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rna-seqblog.com /2 weeks ago

GP-DHT uses single-cell RNA sequencing to map gene regulatory networks

Single-cell RNA sequencing combined with GP-DHT helps predict transcription factor and target gene relationships, providing a...

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journals.plos.org /1 month ago

Regeneration programs buffer genetic defects in animal development

by Kazunori Ando, Sushant Bangru, John Welsby, John D. Thompson, Kenneth D. Poss Regeneration programs enable animals to restore damaged or lost tissues, and the range of stimuli...

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bioengineer.org /1 day ago

Regulatory Evolution Offers Clues to Horn Diversification in Beetles

A comparative study in two beetle species links evolving regulatory DNA and condition-specific chromatin changes to horn diversification, with functional evidence for two BMP-pathw...

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bioengineer.org /1 month ago

CRISPR Methylation Editing Rewrites the Cancer Epigenome Toward Causation

Cancer has long been understood as a disease of the genome, driven by mutations that rewire the instructions encoded in DNA. Over the past three decades, however, a parallel truth...

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journals.plos.org /1 day ago

The role of gene regulatory evolution in weapon diversification: Insights from comparative genomics, chromatin profiling...

by Phillip L. Davidson, Isabel G. Manley, Armin P. Moczek Condition-responsive growth is a common feature of multicellular development, during which organisms integrate genetic an...

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bioengineer.org /1 month ago

Improved spike-in normalization reveals how active histone modifications relate to transcription

Chromatin, the molecular packaging system that compacts DNA inside the nucleus, is not merely a passive storage device. By loosening or tightening access to genetic material, it he...

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nanowerk.com /1 month ago

Researchers discover DNA organization is key to tissue regeneration

Researchers show that long-range chromatin loops help control tissue regeneration, revealing a direct role for 3D genome organization in regenerative processes.

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journals.plos.org /1 month ago

METTL1-mediated m<sup>7</sup>G modification regulates hair follicle cycle via the HOXC13/FOXN1/DSG4 axis

by Xinyan Gan, Qiwen Li, Qiuchan Xiong, Denghao Huang, Zizheng Liu, Qi Yin, Shuang Jiang, Takuma Matsubara, Shoichiro Kokabu, Wei Yan, Quan Yuan Rapid hair follicle cycling requir...

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rna-seqblog.com /1 week ago

Machine learning reveals how RNA splicing is regulated in individual cell types

Researchers developed CASREL, a machine learning framework that uses single-cell RNA sequencing to identify potential regulators of alternative splicing across different tissues an...

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nanowerk.com /3 weeks ago

Researchers develop a genetic switch that works in both bacteria and yeast

Researchers developed a synthetic promoter that works across bacteria and yeast, enabling more transferable gene control for microbial biomanufacturing.

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genengnews.com /2 weeks ago

The Epitranscriptome Heads Toward Clinical Necessity

Short-read RNA sequencing reporting the modifications that alter protein output is starting to make epitranscriptomics indispensable for patient selection in precision medicines. T...

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arstechnica.com /1 month ago

Google's AI genome system evaluates every possible one-base change

Most one-base changes to the human genome do nothing, but a few are significant.

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bioengineer.org /1 week ago

Where a Gene Sits on the Bacterial Chromosome May Shape Its Expression Through Selection

A new PLOS Genetics study finds that bacterial gene positions along the chromosome show gradients in mean and growth-dependent expression consistent with selection shaped by replic...

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journals.plos.org /1 month ago

The carbohydrate utilization regulator Cbr1 coordinates nutrient-specific gene activation with selective carbon cataboli...

by Brandon Reyes-Chavez, Joshua D. Kerkaert, Lori B. Huberman Cells must sense and respond to nutrients to survive. To efficiently grow in mixed carbon environments, microbes repr...

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genengnews.com /2 weeks ago

DNA Typewriter, PEtracer Map Mouse Development Through Organogenesis

Two DNA-recording systems traced cellular family trees across mouse embryogenesis, offering new insight into how organs form and when developing cells commit to specific fates. The...

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genengnews.com /3 weeks ago

Genome-Wide Analysis Identifies BACH2 as Potential Fetal Hemoglobin Activation Target

This pathway, which the authors dub the “BACH2-NRF2 axis,” is independent of the well-known BCL11A transcription regulator, the target of the approved cell therapy Casgevy for sick...

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bioengineer.org /1 month ago

RAS Rewires Ribosomes, Reshaping How Cells Read the Genetic Code

Cancer cells may be able to reprogram more than gene activity and signaling networks. A study led by researchers at Fudan University and Zhongshan Hospital in Shanghai reports that...

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bioengineer.org /1 month ago

How CsgD Regulates Biofilm Formation and Quorum Sensing in Salmonella Typhimurium

A Master Switch in Salmonella May Link Sticky Biofilms to Bacterial “Social” Signals A gene regulator best known for helping Salmonella build its tough, adhesive biofilms may also...

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journals.plos.org /2 weeks ago

The histone methyltransferase complex subunit RBBP5 serves as a central epigenetic regulator of proteostasis dynamics

by Syeda Kubra, Michelle Sun, William Dion, Yu Bian, Ahmet Catak, Hannah Luong, Haokun Wang, Yinghong Pan, Jia-Jun Liu, Aishwarya Ponna, Lijun Liu, Ian Sipula, Jian-Hua Luo, Michae...

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rna-seqblog.com /1 month ago

Small RNA sequencing reveals regulatory roles for sdRNAs in acute myeloid leukemia

Small RNA sequencing reveals cell-specific sdRNA patterns in AML and healthy hematopoiesis, linking certain snoRNA-derived RNAs to gene regulation and poorer patient outcomes...

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journals.plos.org /1 month ago

Bacterial chromosomal gene positioning is likely shaped by selection on both mean and growth-dependent expression

by Ruiqi Yuan, Jianzhi Zhang In bacteria with circular chromosomes, genes near the replication origin (oriC) are replicated earlier and consequently attain higher copy numbers tha...

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journals.plos.org /3 weeks ago

The SynMuvA <i>lin-15A</i> licenses natural transdifferentiation by antagonizing identity safeguarding mecha...

by Sarah Frieda Becker, Marie-Charlotte Morin, Julien Lambert, Shashi Kumar Suman, Francesco Nicola Carelli, Alex Appert, Stéphane Roth, Sarah Hoff-Yoessle, Jessica D. Medina-Sanch...

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