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bioengineer.org /1 month ago

Revolutionizing Gene Editing: Enhancing Delivery Systems Through Cellular Factory Re-Engineering

Gene editing represents one of the most transformative advances in modern medicine, offering the potential to correct genetic diseases at their source. However, a major obstacle in...

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nanowerk.com /1 month ago

New gene editing method inserts large DNA segments to rewrite genome chapters

A new prime assembly technique inserts DNA segments up to 11,000 base pairs into the genome, enabling correction of thousands of mutations at once.

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bioengineer.org /2 weeks ago

UMass Chan Scientists Pioneer Gene Editing Technology That Rewrites Entire Genome Chapters

Scientists at UMass Chan Medical School have pioneered a groundbreaking gene editing technology named “prime assembly,” which challenges the limitations of traditional genome editi...

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genengnews.com /4 weeks ago

Gene Editing at Scale, Clinic Seeks Generalizable Therapies

What’s most exciting about CRISPR is its potential to shift medicine from managing disease to directly correcting its root cause. End-to-end pipelines and regulatory advances aim t...

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genengnews.com /1 month ago

Expanding the Toolbox for Mammalian Genome Engineering

Despite significant advances in genome editing technologies over the past decade, integrating large DNA payloads into mammalian genomes efficiently, site-specifically, and safely h...

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genengnews.com /2 weeks ago

DNA‑Guided CRISPR Suggests a New Direction for RNA Editing

The platform, called ΨDNA, reprograms Cas12 nucleases to recognize and act on RNA using a DNA-based guide scaffold. In human cell lines, ΨDNA achieved 70–95% knockdown of endogenou...

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nanowerk.com /1 month ago

Building a better delivery system for gene editing machines by re-engineering the cellular factory

A new study improves gene editing delivery by engineering the human cells that produce virus-like particles, boosting the potency of these key therapeutic vehicles.

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bioengineer.org /1 month ago

Non-Viral Large DNA Integration in Human T Cells

A groundbreaking advancement in gene editing heralds a new era for immunotherapy, addressing the longstanding challenges of integrating large DNA sequences into primary human T cel...

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jdsupra.com /2 weeks ago

FDA Issues Draft Guidance on Safety Testing for Gene Editing Therapies

On April 14, 2026, the United States Food and Drug Administration (“FDA”) issued a draft guidance for sponsors seeking approval of human gene-editing therapy products involving gen...

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bioengineer.org /3 weeks ago

HKUST Researchers Pioneer World’s First DNA-Guided Gene Editing Tool, Revolutionizing Infectious Disease Diagnosis and A...

In a remarkable leap forward in gene editing technology, researchers at The Hong Kong University of Science and Technology (HKUST) have developed the world’s first DNA-guided CRISP...

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nanowerk.com /1 month ago

CRISPR variant selectively targets tumor DNA

New gene-editing techniques exploit unique chemical fingerprints in cancer DNA to selectively destroy tumor cells, paving the way for precision therapy.

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genengnews.com /1 month ago

Retron-Powered Approach Enables Genome Editing Across Diverse Bacterial Species

By adapting a retron-based editing system from E. coli to 15 bacterial species, scientists reveal a genome editing platform that could accelerate studies of pathogens, microbial in...

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genengnews.com /1 month ago

Engineered Miniature CRISPR Boosts Gene‑Editing Efficiency in Human Cells

A newly characterized Cas12f nuclease shows strong editing in human cells. Researchers engineered a variant with markedly improved efficiency, advancing efforts toward compact geno...

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news-medical.net /1 month ago

Non-clinical safety assessment crucial for CRISPR-based gene therapies

The rapid evolution of CRISPR/Cas genome editing has redefined the possibilities of cellular and gene therapy, enabling precise correction, disruption, and regulation of disease-as...

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genengnews.com /1 month ago

Genetic Medicine Delivery Enhanced by Producer Cell Modifications

A new platform based on genome-wide screening systemically identifies which genes drive or block particle assembly to engineer cells that yield more potent delivery vehicles. The...

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rna-seqblog.com /1 month ago

New FDA recommendations support next-generation sequencing-based safety evaluation of off-target editing for personalise...

FDA draft guidance highlights next-generation sequencing approaches for evaluating off-target effects and genomic integrity in genome editing therapies, supporting safer gene thera...

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genengnews.com /1 month ago

Stem Cell Editing Programs the Immune System to Make Own Therapeutic Proteins

A new gene‑editing strategy programs hematopoietic stem cells to produce therapeutic antibodies and other proteins. The approach generates long‑lasting immunity in mice and could p...

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bioengineer.org /1 month ago

Base Editing Rescues Cardiac Fabry Mutation in Cells

In a landmark advance for genetic medicine, researchers have unveiled a groundbreaking approach to correcting a cryptic splice mutation responsible for cardiac-type Fabry disease....

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medcitynews.com /1 month ago

Intellia’s Data Reveal Tees Up FDA Filing for CRISPR-Based In Vivo Gene-Editing Med

Intellia Therapeutics’ lonvo-z uses CRISPR to inactivate a gene in the liver to reduce levels of a protein key to the swelling attacks from the rare disease hereditary angioedema....

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genengnews.com /1 month ago

CRISPR Base Editing Repairs Hard-to-Treat Cystic Fibrosis Mutation in Cell Models

By applying base editing, scientists repaired a cystic fibrosis mutation that is unresponsive to current drugs in cell and organoid models, pointing to a possible treatment for som...

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genengnews.com /2 weeks ago

ASGCT 2026: AI-Optimized Cas12l Gene Editor Offers Compact Cas9 Alternative

The CEO of Caszyme, a biotech company in Vilnius, Lithuania, presented details of Cas12l, a novel compact Cas nuclease with a variety of potential research and therapeutic applicat...

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labiotech.eu /1 month ago

Modified CRISPR tool targets Down syndrome mutation

Researchers have used modified CRISPR to silence the extra chromosome 21 in Down syndrome cells, showing promising preclinical results. The post Modified CRISPR tool targets Down s...

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genengnews.com /1 month ago

Rewriting CAR T From Within

In vivo engineering strategies promise faster, scalable cell therapies and a streamlined path from discovery to clinical development. The post Rewriting CAR T From Within appeared...

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discovermagazine.com /1 day ago

Gene Editing May Help Treat Dangerously High Cholesterol with Just One Infusion

Learn how gene editing may help people born with dangerously high cholesterol lower their levels with just one infusion.

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