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A genome-scale CRISPRi atlas maps transcriptional consequences for 11,692 gene perturbations across more than 2.5 million human iPSCs. The resource reveals regulators of metabolism...
MERCURIUSâ„¢ 1536 DRUG-seq brings RNA sequencing to large-scale compound screening, enabling efficient gene expression profiling... The post Alithea Genomics launches early access...
RNA sequencing combined with high-throughput functional profiling enabled researchers to build complete riboswitch models and uncover coordinated structural changes involved in gen...
Advances in end-to-end multiomics platforms and the underlying scientific knowledge now enable faster and more precise biomarker discovery, mechanistic insight generation, and ther...
RNA sequencing supports space biology research by enabling transcriptome-wide analysis of gene expression changes associated with spaceflight and adaptation to space environments.....
Genomics tools—applied to agriculture—create commercially desirable traits in a fraction of the time required by standard breeding programs. The post Ag Genomics Begins to Bear Fru...
Scientists created an AI tool that can help to reveal how genes function together inside human cells dependent on the cellular context, which could ultimately help to support the d...
by Debomita Chakraborty, Raghunathan Rengaswamy, Karthik Raman A unique balance of seemingly contradictory properties like robustness and plasticity, or evolvability and functiona...
TAP-seq combines genome editing with targeted RNA sequencing to enable sensitive and cost-effective single-cell functional genomics screens...
by Jean Fan Since the founding of PLOS Computational Biology 20 years ago, genomics research has advanced at a remarkable pace. In this 20th anniversary commentary, as an Editor f...
D&D‑seq uses a base editor–nanobody fusion to record DNA–protein contacts at single‑cell resolution. The method maps transcription factor and chromatin-remodeling proteins. The...
RNA sequencing from more than 22 million cells trained a model that predicts cell-type-specific gene expression and noncoding variant...
In a detailed cellular study of Crohn’s disease, researchers mapped how gene activity changes across more than 50 cell types in the gut and created an open resource, IBDverse, char...
Researchers have created the world's first graph-based mung bean pan-genome, revealing genetic variations linked to yield, nutrition, and pest resistance, and providing breeders wi...
RNA sequencing with regRNA Capture-seq identified thousands of regulatory RNAs and enabled new strategies to increase expression of disease-related genes using ASOs...
Deep learning unveils how drugs affect the dynamics of key structures within the cell. A new study maps condensate morphology to functional outcomes and sheds light on markers of h...
Papers note that repetitive DNA — the type of DNA that our junk-DNA-defending friends assure us must be functionless — is vital for forming G4 structures. Source
RNA sequencing is becoming part of routine healthcare, making genomic literacy essential for clinicians, researchers, and patients to accurately interpret results and support infor...
Scientists have, for the first time, used an extremely precise genome editing technique called base editing to study gene function in human embryos.
RNA sequencing joins genomic, proteomic, and clinical data in the expanded NIH All of Us database, creating an unprecedented resource for precision medicine research...
New chromatin‑based analysis of 1,563 AML samples reveals 16 epigenomic subgroups that improve prognostic accuracy and highlight unexpected drug sensitivities. The post Epigenomic...
This eBook explores how researchers can move beyond correlation and towards mechanism in microbiome research—from preserving physiologically relevant microbial communities to direc...
A newly developed open-source tool designed for rigorous reanalysis of genomic data is highly effective at detecting new rare disease diagnoses. The tool's ability to frequently an...
A new blood-test platform enables noninvasive monitoring of gene expression in living tissues over time, complementing RNA sequencing approaches for studying disease progression......
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