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Factor VIII (FVIII) replacement therapy is a cornerstone of treatment for many people with hemophilia A, a rare bleeding disorder caused by deficient or dysfunctional FVIII, a prot...
Albumin fusion is a molecular technology that has been used to create replacement therapies for hemophilia with an extended half-life — treatments that are more long-lasting in the...
Due to my husband Jared’s severe hemophilia B, we keep a small, personal supply of factor replacement therapy in our refrigerator that typically is enough to cover one bleeding eme...
Xyntha (moroctocog alfa) is a recombinant clotting factor replacement therapy approved to prevent and treat bleeds, including those occurring during surgery, in people with hemophi...
Rebinyn (nonacog beta pegol) is a recombinant factor IX concentrate used to prevent and treat bleeds, including those occurring during surgery, in children and adults with hemophil...
How far can one go, practically speaking, and in the relatively near future, to develop therapies to treat aging based on replacement of worn parts? Some forms of replacement thera...
It seems a little early in the development of partial epigenetic reprogramming as a class of therapy to be thinking about which of the other approaches to aging it can best be comb...
Inside the evolving hemophilia treatment landscape, including AAV-based gene therapies, non-factor prophylaxis, and approaches that aim to reduce treatment burden. The post Gene an...
A look at how FVIII/FIX deficiency contributes to variable disease severity and provides the biologic foundation for modern hemophilia therapies. The post Bleeding Response in Hemo...
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