Search results for Extracellular Matrix Remodeling

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journals.plos.org /4 days ago

Pre-cuticle DPY-6 acts as a blueprint for aECM periodic organization in <i>C. elegans</i>

by Sophie Mazzoli, Thomas Sonntag, Emma Cadena, Claire Valotteau, Susanna K. Birnbaum, Meera V. Sundaram, Nathalie Pujol Apical extracellular matrices (aECMs) are essential for ti...

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bioengineer.org /3 weeks ago

RHOV Links EMT Plasticity to Cancer Invasion

In the relentless quest to understand the mechanisms underpinning cancer metastasis, a groundbreaking study has unveiled the pivotal role of a protein named RHOV as a key molecular...

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bioengineer.org /3 weeks ago

CD248 Controls Fibroblast Mechanosensing in Kidney Fibrosis

In a groundbreaking study set to redefine our understanding of renal fibrosis, researchers have identified a novel mechanosensory role for the protein CD248 in fibroblast subpopula...

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bioengineer.org /1 week ago

Targeting S100A4–TLR4–TGF-β Axis in Diabetic Dupuytren’s

In a groundbreaking study published in Cell Death Discovery, researchers have unveiled a complex molecular pathway that may pave the way for transformative therapeutic strategies t...

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kidney-international.org /4 weeks ago

Communication leading to injury: podocyte-derived fibrillin-1 induces mesangial cell activation and proliferation throug...

The mechanism by which podocyte injury induces mesangial activation, a pathologic hallmark of glomerulosclerosis, is poorly understood. In this issue of Kidney International, He et...

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fightaging.org /3 weeks ago

Examining the Extracellular Matrix of Skin in Long-Lived Naked Mole-Rats

Naked mole-rats live very much longer than other similarly sized rodents, and exhibit very little age-related decline until very late life. Researchers use this species as a point...

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bioengineer.org /1 month ago

Exocyst Component 5 Deletion Hinders Kidney Repair

In a groundbreaking study set to reshape our understanding of kidney regeneration, researchers have unveiled the pivotal role played by a key cellular component known as exocyst co...

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bioengineer.org /1 month ago

Fibroblast Lipids Drive Epithelial Cancer Invasion Rates

In a groundbreaking advancement that could redefine how we understand and combat oral squamous cell carcinoma (oSCC), researchers have unearthed pivotal roles for tissue-specific f...

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bioengineer.org /1 month ago

Engineered Dendritic Cells Prevent Cardiac Remodeling

Heart failure, a devastating condition characterized by the heart’s inability to pump blood efficiently, remains a leading cause of global morbidity and mortality. Despite advances...

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bioengineer.org /1 week ago

Embryonic Cell Migration: The Journey of Life Begins

In a groundbreaking study published in Nature Communications, scientists from the Institute of Science and Technology Austria (ISTA) and their collaborators at Sorbonne Université...

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kidney-international.org /1 month ago

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease

The maintenance of a healthy epithelial-endothelial juxtaposition requires crosstalk within glomerular cellular niches. Here, we sought to understand the spatially anchored regulat...

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bioengineer.org /3 weeks ago

Catecholaminergic Neurons Enhance Keloid Fibroblast Bone Growth

In a groundbreaking study set to transform our understanding of fibrotic skin disorders, researchers have uncovered a novel cellular interaction driving the abnormal bone-like tiss...

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bioengineer.org /4 weeks ago

Precise Spatiotemporal Cardiac Repair and Regeneration

In the rapidly advancing landscape of cardiovascular medicine, the future of treating myocardial infarction is being reshaped by groundbreaking developments in spatiotemporal drug...

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nanowerk.com /3 weeks ago

Piezoelectric MXene scaffold promotes cartilage repair while limiting vessel growth

An origami scaffold uses electrical repair cues and light-triggered heating to promote cartilage formation while limiting vessel growth beneath the defect.

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bioengineer.org /1 week ago

Deep Phenotyping Reveals Skin Remodeling in Sclerosis Treatment

In a remarkable stride toward combating systemic sclerosis, an aggressive connective tissue disease marked by skin thickening and fibrosis, a team of researchers has unveiled groun...

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journals.plos.org /2 weeks ago

Exploring the relationship between vascular remodelling and tumour growth using agent-based modelling

by Nicholas Fan, Joshua A. Bull, Helen M. Byrne We develop a multiscale agent-based model (ABM) to investigate the effect that mechanical interactions between proliferating tumour...

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lifespan.io /2 days ago

Early Cancer Cells Change Their Surroundings to Form Tumors

Scientists have demonstrated how cancer cells influence neighboring cells to create a favorable niche for the tumor to grow. Understanding this can inform future early-stage cancer...

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bioengineer.org /1 month ago

Hydrogel with AAV8-sTβRII Reduces Skin Scars

In the quest to transform wound healing and reduce the chronic burden of scarring, a groundbreaking gene therapy approach has emerged, combining cutting-edge biomaterials with prec...

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bioengineer.org /1 month ago

How Cells Determine When to Respond Could Transform Future Cancer and Fibrosis Treatments

Cells are not only able to sense physical forces in their environment but also possess an intrinsic ability to measure the duration of these forces before mounting a response. This...

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bioengineer.org /1 month ago

Mammary Organoid Depot Enables Post-Surgery Chemo, Regeneration

In the relentless battle against breast cancer, the challenge of preventing tumor recurrence after surgical intervention has remained a formidable obstacle. Traditionally, post-sur...

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bioengineer.org /3 weeks ago

Estrogen Deficiency Triggers Bone EVs Causing Cell Aging

In a groundbreaking study published in Experimental & Molecular Medicine on May 7, 2026, researchers have unveiled a novel molecular mechanism by which estrogen deficiency impa...

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