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Here is yet another clue about how we are both spiritual and physical beings. The two realms are connected in mysterious and remarkable ways. Source
Because we are dealing with foundational scientific discoveries, we will address several “So what?” questions. Source
Traditional gene editing rewrites DNA. But a new approach, called epigenome editing, aims to treat the molecular scars we collect throughout our lives.
Atlases like this one can provide the labeled, cell-type-resolved training data that artificial intelligence models need to make accurate predictions—a bottleneck that has historic...
Cancer does not merely rewrite the genetic letters of the genome; it can also reorganize the vast three-dimensional structure in which those letters are stored. A new review by Fra...
Alzheimer’s may scramble the genome’s 3D structure inside brain cells, disrupting the genetic controls that keep the brain functioning. The human genome is not simply packed into b...
by Ezra E. Amiri, Muzi Li, Ayse Tenger-Trolander, Maxwell Devine, Alexander T. Julian, Koray Kasan, Sheri A. Sanders, Shelby A. Blythe, Urs Schmidt-Ott Establishing the anterior-p...
Every mechanism of aging influences all of the other mechanisms of aging. Our biology is a big tangled ball of interactions. As a follow up to a recent post on the connection betwe...
Scientists linked early-life stress experience in mice to long-term stress hypersensitivity within the brain’s dopaminergic circuitry, providing a mechanism by which early-life str...
A new study reveals that the human brain undergoes major shifts in 3D genome architecture and gene regulation starting in midlife.
Chromatin, the molecular packaging system that compacts DNA inside the nucleus, is not merely a passive storage device. By loosening or tightening access to genetic material, it he...
Every masterpiece can be traced to its master designer — the architect. Sagrada Família is no exception. Source
A study of worms finds a protein that helps shape the structure of the genome is critical for establishing the identity of some neurons.
In the earliest hours of a sea lamprey embryo’s life, something remarkable happens. As its cells divide, vast stretches of genetic material—entire chromosomes—are...
You are the science news desk of a major English-language science magazine. Complete the task immediately. Never ask the reader what to do, never offer editing options, and never r...
A new single-cell technology is giving researchers an unusually complete view of how individual cells establish and change their identities. Called OneCell CUT&Tag, the method...
Jonathan Wells’s review was important, but it only scratches the surface of information in biology outside of the DNA. Source
Researchers reveal that radial glial progenitor lineage progression in cortical organoids differs from the developing mouse brain, highlighting the importance of stem-cell niche si...
These are the same type of understandable and logical computation circuits that humans design. What can we learn from observing this similarity? Source
A new study shows that 3D genome architecture is altered in prefrontal cortex cells of individuals with Alzheimer's disease.
DNA regulatory elements, which control when, where, and to what extent specific genes are turned on or off, can be co-opted by scientists to create gene switches. The post Gene Sw...
SKIN THE ARCHITECT is an interactive installation by LAIDA - the Latvian Architecture and Design Union - created in response to the theme of this year's Tallinn Architecture Bienna...
by Luisa Quesada Camacho, Mohammad Fallahi-Sichani Epigenetic dysregulation is a common feature of cancer. It creates vulnerabilities arising from an increased reliance on chromat...
Protective mesh-like structures, called perineuronal nets, stabilize memory circuits and unexpectedly diminish during late adolescence before rebuilding in adulthood. The post Memo...
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