Latest updates for Epigenetics And The Architect

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Recent items include:

  • A Newer Kind of Gene Editing Promises to Edit ‘Nurture’ Over ‘Nature’
  • CRISPR Methylation Editing Rewrites the Cancer Epigenome Toward Causation
  • The Polycentric Aging Framework Positions Epigenetic Change as the Dominant Mechanism of Aging

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nytimes.com /1 month ago

A Newer Kind of Gene Editing Promises to Edit ‘Nurture’ Over ‘Nature’

Traditional gene editing rewrites DNA. But a new approach, called epigenome editing, aims to treat the molecular scars we collect throughout our lives.

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bioengineer.org /1 month ago

CRISPR Methylation Editing Rewrites the Cancer Epigenome Toward Causation

Cancer has long been understood as a disease of the genome, driven by mutations that rewire the instructions encoded in DNA. Over the past three decades, however, a parallel truth...

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fightaging.org /3 days ago

The Polycentric Aging Framework Positions Epigenetic Change as the Dominant Mechanism of Aging

The presently available data and understanding of aging might be thought of as a jigsaw with more missing pieces than there are pieces in hand. There is a great deal of latitude to...

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journals.plos.org /2 weeks ago

Epigenetic maintenance of PRC2-repressed chromatin requires RTT109 but not H3K56 acetylation

by Rochelle E. Yap, Felicia Ebot-Ojong, Abigail J. Ameri-Solanky, Zachary A. Lewis In animals, plants, and some fungi, Polycomb Repressive Complex 2 (PRC2) catalyzes trimethylatio...

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journals.plos.org /2 weeks ago

The histone methyltransferase complex subunit RBBP5 serves as a central epigenetic regulator of proteostasis dynamics

by Syeda Kubra, Michelle Sun, William Dion, Yu Bian, Ahmet Catak, Hannah Luong, Haokun Wang, Yinghong Pan, Jia-Jun Liu, Aishwarya Ponna, Lijun Liu, Ian Sipula, Jian-Hua Luo, Michae...

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genengnews.com /2 weeks ago

DNA Typewriter, PEtracer Map Mouse Development Through Organogenesis

Two DNA-recording systems traced cellular family trees across mouse embryogenesis, offering new insight into how organs form and when developing cells commit to specific fates. The...

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dev.to /1 month ago

Inherited Memory Helped My Flies Until the World Changed. Then a Blank Slate Beat Them.

Earlier in this series I killed a brain and the memory lived through it. Then I dropped that memory into a fresh brain, and the fresh brain woke up believing a life it never lived...

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bioengineer.org /1 month ago

Sea lamprey embryo studies reveal roles of histone methyltransferases in DNA elimination

In the earliest hours of a sea lamprey embryo’s life, something remarkable happens. As its cells divide, vast stretches of genetic material—entire chromosomes—are...

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bioengineer.org /1 month ago

Divergent epigenetic profile underlie pubertal disorders in MKRN3-associated central precocious puberty and Prader–Willi...

You are the science news desk of a major English-language science magazine. Complete the task immediately. Never ask the reader what to do, never offer editing options, and never r...

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nanowerk.com /4 weeks ago

A single temporary stimulus can redirect cell fate without permanent gene control

A new computational framework that identifies minimal temporary gene-control interventions to steer cells toward desired states while preserving cellular plasticity.

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archdaily.com /1 month ago

Skin the Architect

SKIN THE ARCHITECT is an interactive installation by LAIDA - the Latvian Architecture and Design Union - created in response to the theme of this year's Tallinn Architecture Bienna...

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futurity.org /1 month ago

Team finds new layer of the human genome

New findings could change how scientists think about DNA organization, transcription, and genome function.

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journals.plos.org /1 month ago

Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenet...

by Luisa Quesada Camacho, Mohammad Fallahi-Sichani Epigenetic dysregulation is a common feature of cancer. It creates vulnerabilities arising from an increased reliance on chromat...

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journals.plos.org /3 days ago

The role of gene regulatory evolution in weapon diversification: Insights from comparative genomics, chromatin profiling...

by Phillip L. Davidson, Isabel G. Manley, Armin P. Moczek Condition-responsive growth is a common feature of multicellular development, during which organisms integrate genetic an...

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legaltechmonitor.com /3 weeks ago

Beyond the Wet Lab Bottleneck: The Race to Build Biology’s Generative Engine

Cambridge, MA – MIT Media Lab – EmTech Future. Nature has spent roughly 3.8 billion years conducting the most sprawling, creative research and development campaign in history. Evol...

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fightaging.org /3 weeks ago

Accelerated Epigenetic Aging Correlates with Later Loss of Memory Function

Aging clocks have yet to fulfill their promise, which is to produce a robust measure of biological aging that can be used to rapidly assess the results of potential therapies to sl...

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rna-seqblog.com /1 month ago

ARCADIA combines RNA sequencing and spatial proteomics to reveal how tissue location shapes cell behavior

ARCADIA integrates single-cell RNA sequencing with spatial proteomics to reveal how tissue neighborhoods influence B-cell maturation, T-cell activation, and other transcriptional p...

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bioengineer.org /1 month ago

Fruit Fly Genomes Reveal How Circadian Clocks Evolve and Adapt

The daily rhythms that govern life on Earth—from the sleep-wake cycles of humans to the emergence of insects from their pupal cases—are orchestrated by an internal molecular timeke...

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sciencealert.com /1 month ago

Everyone Assumes DNA Shapes Your Personality. It Turns Out Something Else Is Doing Most of The Work

Written in genetic code.ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story, subscribe here.

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journals.plos.org /2 weeks ago

DeCTCF: Decoding CTCF binding sequences by leveraging predicted epigenomic features

by Lu Chai, Jie Gao, Tinghe Guo, Teer Ba, Zihan Li, Junjie Liu, Yong Wang, Lirong Zhang CTCF is a key architectural protein with diverse roles in genome organization and gene regu...

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genengnews.com /2 weeks ago

The Epitranscriptome Heads Toward Clinical Necessity

Short-read RNA sequencing reporting the modifications that alter protein output is starting to make epitranscriptomics indispensable for patient selection in precision medicines. T...

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genengnews.com /2 weeks ago

Epigenetics Underlies Comparatively Accelerated Molecular Aging in Larger and Male Dogs

Large dogs tend to be shorter lived than their smaller counterparts, and a new study found that male and larger dogs undergo accelerated molecular aging, with pronounced DNA methyl...

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archdaily.com /2 weeks ago

Architecture as Translation: Africanfuturism in Folklore, Film, and Speculative Art

"Take your dream suppressants." The opening line in Wanuri Kahiū's Pumzi, directed at our protagonist Asha, enforces the order of severing ties with hopeful futures and ancestral...

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bioengineer.org /3 days ago

Regulatory Evolution Offers Clues to Horn Diversification in Beetles

A comparative study in two beetle species links evolving regulatory DNA and condition-specific chromatin changes to horn diversification, with functional evidence for two BMP-pathw...

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