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Scientists unveiled a reaction that swaps key carbon groups in complex compounds, offering a faster route to test new medicine candidates.
ProBio is building flexible platforms for multispecific antibodies, ADCs, and other advanced therapeutic approaches. The post From Discovery to Development in Emerging Modalities a...
Delve into the hidden innovation system of drug repurposing. When patents expire and commercial value fades, a new wave of research starts. The post The hidden innovation system be...
Advances in end-to-end multiomics platforms and the underlying scientific knowledge now enable faster and more precise biomarker discovery, mechanistic insight generation, and ther...
AI will continue changing how small molecules are discovered, but the candidates that generate the most interest in silico still have to succeed under real development conditions....
Despite remarkable progress in medical science, the prognosis for most patients diagnosed with advanced-stage cancers remains bleak. The challenge lies not only in the complexity o...
As researchers work to develop new cancer treatments, one of the biggest challenges is identifying promising drug candidates quickly and efficiently. Now, researchers at Purdue Uni...
A new method screens large libraries of synthetic cyclic peptides to identify compounds that can enter cells for therapeutic effect, opening avenues for a modality that combines th...
Next-generation MS platforms are transforming drug discovery by revealing complex biology earlier, faster, and at unprecedented depth. The post Mass Spectrometry’s Discovery Revolu...
David Baker’s latest company is making medicines for a huge protein family once deemed undruggable. A new study generated miniproteins that target GPCRs across a diversity of recep...
ZoBio maintains that unlike transactional DEL screening approaches that focus solely on hit generation, its platform is designed to deliver biologically relevant, structurally char...
In early discovery, researchers use high-throughput screening (HTS) to identify active compounds in a biologically relevant context. During lead characterization and validation, th...
Insider Brief It’s one thing to design a pharmaceutical drug. It’s another to know if and why it actually works. Not on paper or in a computer model. But inside the chaotic world o...
Researchers used two AI systems, Robin and Co-Scientist, to collapse the timeline from idea to drug candidate. The post AI Lab Partners Are Rewiring the Hunt for New Drugs appeared...
Discover why animal models fall short in AI drug discovery and how human-first datasets are changing that. The post How human-first datasets are reshaping AI drug discovery appeare...
Deep learning unveils how drugs affect the dynamics of key structures within the cell. A new study maps condensate morphology to functional outcomes and sheds light on markers of h...
AI can speed up drug discovery and decrease attrition rates in the clinic, but it is important to recognize that both are tall orders. The companies that will benefit most are thos...
Macrocycles, de novo antibodies, and mRNA therapies are expanding the drug discovery toolbox for unmet patient needs. The post Novel Therapeutic Modalities Target the Undruggable a...
New AI‑designed miniproteins precisely modulate GPCR signaling and reveal a new "receptor diversion" microscopy-based screening system for targeting receptors long considered diffi...
In the quest for faster and more efficient drug discovery, researchers have uncovered a novel method to enhance molecular complexity using a surprisingly straightforward tool: blue...
Drug discovery is notoriously inefficient. Pharmaceutical projects span years, moving from one specialized human team to the next through disconnected workflows that result in know...
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