Early high-efficacy MS drugs cut relapse risk, not progression
Early treatment with high-efficacy disease-modifying therapies (DMTs) lowered the risk of relapse-associated disability progression in people with multiple sclerosis (MS), but had...
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Early treatment with high-efficacy disease-modifying therapies (DMTs) lowered the risk of relapse-associated disability progression in people with multiple sclerosis (MS), but had...
Daruwalla et al. Treatment escalation after clinically silent MRI lesions in relapsing-remitting multiple sclerosis. Brain. 2026 Jul 24:awag252. Clinically silent MRI lesions occur...
The MS world is changing and the advent of anti-CD20 depleting antibodies has allowed this to happen. For many years you had to get rid of T cells to control MS and that would give...
I’ve done natalizumab, alemtuzumab, anti-CD20 and cladribine use, now is the time to look at the laggards. Where are the lower efficacy treatments being used. Don’t get me wrong th...
Following on from the post on subcutaneous ofatumumab and intravenous ocrelizumab we had a question. “Is the Subcut version of Tysabri as effective as the infusion based on the cur...
Dann J, Klöster K, Ceylan U, Heitmann N, Eggers B, Rozanova S, Eisenacher M, Marcus-Alic K, Winklhofer KF, Gold R, Faissner S. Monomethyl Fumarate Modulates Iron Metabolism and Mit...
Maal AB, Arki MK, Nabavi SM, Rezaei-Tavirani M, Rismani E, Vosough M, Azizi G, Hossein-Khannazer N. Immune reconstitution and tolerance-inducing therapies as promising therapeutic...
An experimental oral drug called remibrutinib outperformed the approved therapy Aubagio (teriflunomide) in reducing disease flare rates in two large, late-stage clinical trials inv...
Ocrelizumab is licenced for relapsing and active primary progressive MS (Lesions and relapses) in the EU…It is active because we know it works by stopping B cells from entering the...
In MS we do not know of a definative target. But in neuromyelitis optic a demyelinating condition of the spinal cord and optic nerves is associated with antibodies against a water...
People with relapsing-remitting multiple sclerosis (RRMS) who show even a single silent lesion on an MRI scan while taking a lower- or moderate-efficacy disease-modifying therapy (...
A new experimental cell therapy that pairs a patient’s own red blood cells with myelin protein fragments safely calmed the immune system and helped dampen the inflammatory attack t...
There are lots of different B cell depleting antibodies used in cancer and autoimmunity. There are three approved for MS (in blue below. Ublituximab, ocrelizumab and ofatumumab), b...
Yang Y, Bai B, Knutsen LJS, Hamlyn RJ, Cui QL, Antel J, Macklin W, Medicetty S, Trapp BD. A novel small molecule remyelination therapy for multiple sclerosis. NPJ Drug Discov. 2026...
A cell therapy called deramiocel could slow muscle weakening in boys and young men with advanced Duchenne muscular dystrophy (DMD) and may also slow heart damage in those who alrea...
So rather than about 100 people using alemtuzumab, it is about 20,000 people recieving an anti-CD20. Remember this is an underestimate. Also the data has not been repeated I have e...
Nerve damage is a consequence of poorly controlled MS and in one place it is easy to monitor nerve damage and this is in the eye. The eye is connected to your brain and nerve damag...
Ocrevus (ocrelizumab) and Kesimpta (ofatumumab) are both highly effective at preventing relapses and disability worsening in people with relapsing-remitting multiple sclerosis (RRM...
Inside the evolving hemophilia treatment landscape, including AAV-based gene therapies, non-factor prophylaxis, and approaches that aim to reduce treatment burden. The post Gene an...
An investigational anti-TL1A monoclonal antibody achieved “clinically meaningful” outcomes compared with placebo in patients with inflammatory bowel disease, according to results o...
The answer to this is unlikely to occur from a proper clinical trial done by pharma as it would be dangerous if there is a difference and one seems better than the other. MSBase is...
ProfK has ben magnifying the cladribine natural history and they have got back to where we left off in 2010, when they threw cladribine out with the bath water. They say that cladr...
A drug used to prevent stroke complications may help preserve myelin, the protective coating around nerve fibers that is damaged in multiple sclerosis (MS), according to a review o...
What does a personalised biomarker in anti-CD20 therapy need to measure? CoI: None.
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