Social Media Ideas for Cancer-Associated Fibroblasts

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bioengineer.org /3 weeks ago

Cancer’s Hidden Helpers: Fibroblast Diversity Reshapes How Tumors Spread and How We Treat Them

Cancer rarely travels alone. When tumor cells leave their original home and seed new colonies in distant organs, they are escorted, sheltered, and often actively coached by an ento...

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bioengineer.org /1 month ago

Cancer-associated fibroblast SERPINH1 drives epithelial-mesenchymal transition in clear cell kidney cancer

Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer and remains difficult to control once it advances beyond the kidney. Although immunotherapy, target...

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journals.plos.org /1 month ago

Collagen I promotes cancer cell survival via amino acid import and mTORC1/S6 activation

by Mona Nazemi, Bian Yanes, Eric Vancauwenberghe, Ifeoluwa Oyelade, Heather Walker, Elena Rainero Invasive breast and pancreatic cancer cells thrive within a collagen I-rich, poor...

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bioengineer.org /1 week ago

Collagen Clue: How COL6A1 May Drive Bile Duct Cancer’s Deadly Spread

A new review in Cancer Reports proposes that the extracellular matrix protein COL6A1, overexpressed in the fibrotic stroma of cholangiocarcinoma, may drive tumor progression throug...

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scitechdaily.com /1 month ago

Scientists Discover Hidden Cells That Help Lung Cancer Evade the Immune System

Newly identified CHL1 fibroblasts may help lung cancers escape immune attack by recruiting regulatory T cells around tumors. A previously unknown population of fibroblasts appears...

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bioengineer.org /1 week ago

Oral Cancer Cells Hijack Jaw-Destroying Cells Through an Inflammatory Relay, Study Finds

New research shows that the oncogene ARL4C in oral cancer cells triggers a RelA-dependent inflammatory response in stromal fibroblasts, turning them into a critical source of RANKL...

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bioengineer.org /2 weeks ago

Stem Cell Feeder Platforms Boost Natural Killer Cells for Cancer Immunotherapy

Researchers have developed engineered feeder cells derived from induced pluripotent stem cells that prolong the survival and boost the killing power of natural killer cells, offeri...

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bioengineer.org /4 weeks ago

Staphylococcal Protein Reprograms Liver Tumor Macrophages to Boost Immunotherapy

One of the most stubborn obstacles in cancer immunotherapy is not the tumor cell itself but the cellular entourage that surrounds it. In hepatocellular carcinoma, the most common f...

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bioengineer.org /1 month ago

FAK drives leptin-triggered vessel growth and mimicry in breast cancer

The Satiety Hormone With a Dark Side: Leptin Helps Breast Tumors Build Their Own Blood Supply Leptin, the hormone famous for telling the brain that the body has eaten enough, has b...

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bioengineer.org /2 weeks ago

Hidden armies inside glioblastoma: exhausted T cells hint at new immunotherapy routes

Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be tumor-reactive, opening new avenues for im...

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bioengineer.org /1 week ago

How a Cellular Stress Switch Helps Tumours Hide From the Immune System

A new review reveals how the unfolded protein response, a cellular stress-signalling network, helps tumours evade immune detection and could be targeted to boost cancer immunothera...

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bioengineer.org /2 weeks ago

Immune Cells Cluster Around Blood Vessels to Predict Lung Cancer Immunotherapy Success

Immunotherapy has transformed the treatment landscape for non-small cell lung cancer, the most common form of lung malignancy worldwide, yet a stubborn problem persists: only a sub...

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journals.plos.org /1 month ago

Non-coding RNA 7SK drives tumor resistance by coupling local oncogenic activation with global transcriptional repression

by Ping Xu, Zile Luo, Xi Chen, Zhongyang Yuan, Le Cheng, Yi Yang, Hongcheng Lin, Qiong Zhang, Pengfei Qin The conserved non-coding RNA 7SK is a well-established global transcripti...

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asianscientist.com /3 weeks ago

This Molecular Switch Helps Triple-Negative Breast Cancers Resist Treatment

Researchers uncover how the long non-coding RNA Smyca helps triple-negative breast cancer cells repair DNA damage and survive treatment.

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bioengineer.org /2 weeks ago

Nerves and Tumours Talk: How the Nervous System Drives Cancer Growth and Drug Resistance

Cancer has long been framed as a disease of rogue genes, a story written almost entirely in the language of mutations, checkpoints and clonal evolution. A new review published in M...

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bioengineer.org /1 week ago

Circular RNA Revealed as Hidden Brake on Colorectal Cancer Growth

Researchers report that the circular RNA circMTCL1, sharply depleted in colorectal cancer tumors, suppresses cancer cell growth by sponging miR-145-5p, boosting BMP3, and damping M...

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bioengineer.org /1 month ago

Small Cell Lung Cancer Relies on Targetable Nonsense-Mediated Decay for Immune Control

A Hidden RNA-Decay System May Be the Achilles’ Heel of Small-Cell Lung Cancer Small-cell lung cancer, one of the most aggressive forms of cancer, may depend on a cellular quality-c...

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scitechdaily.com /3 days ago

Scientists Turn a Cancer-Fueling Protein Into a Powerful New Weapon Against Tumors

A protein that helps cancer grow could become an unlikely ally in treating it, with laboratory and mouse experiments showing that activating it in engineered immune cells curbs tum...

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