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A genome-scale CRISPRi atlas maps transcriptional consequences for 11,692 gene perturbations across more than 2.5 million human iPSCs. The resource reveals regulators of metabolism...
TAP-seq combines genome editing with targeted RNA sequencing to enable sensitive and cost-effective single-cell functional genomics screens...
“Guardian of the genome,” p53 is now therapeutically accessible using CRISPR-based technology from Jennifer Doudna’s lab. The approach uses RNA signatures to identify and destroy t...
by Lisa H. Verzier, Eva Hesping, Marcel Doerflinger, Marco J. Herold, Justin A. Boddey Sporozoites of Plasmodium falciparum, the deadliest malaria parasite, are injected into the...
by Emma Källstig, Evelyne Ruchti, Medha Raman, Jamshid Asadzadeh, Bernard L. Schneider, Brian D. McCabe CRISPR/Cas9 based genome editing employing Homology Directed Repair (HDR) f...
Successfully treating Baby KJ with a personalized CRISPR gene-editing therapy is spurring the industry to investigate how to develop standardized manufacturing platforms as well as...
MERCURIUSâ„¢ 1536 DRUG-seq brings RNA sequencing to large-scale compound screening, enabling efficient gene expression profiling... The post Alithea Genomics launches early access...
New spatial RNA sequencing technology links large-scale CRISPR perturbations to tumor growth, metastasis, immune responses, and complex RNA regulation within intact tissues... The...
Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted assas...
Researchers developed PRINCE, a small-molecule-controlled CRISPR system enabling precise, long-term regulation of gene editing. Its compact version, Little Prince, showed therapeut...
This GEN Live show will bring together a panel of leading experts to break down the latest advances, innovations, and challenges shaping genome editing. The post Genome Editing at...
TRIM, an integrated genome engineering platform that combines prime editing, gene knockouts, and large-scale chromosome engineering, enabled efficient stacking of multiple benefici...
In a groundbreaking advancement that sets a new paradigm in genetic medicine, researchers at Amsterdam University Medical Center (Amsterdam UMC), collaborating with several interna...
A handful of start-up firms are testing therapies that target specific epigenetic markers to treat everything from high cholesterol to a rare muscular disorder
As genome editing therapies move through clinical trials to regulatory approval, scientists continue the quest for the holy grail of large-scale DNA editing.. The post The Quest fo...
RNA sequencing with regRNA Capture-seq identified thousands of regulatory RNAs and enabled new strategies to increase expression of disease-related genes using ASOs...
In the wake of the 2025 Mpox outbreak that extensively affected Sierra Leone, a groundbreaking scientific advancement has been reported, spearheading diagnostic methodologies and e...
Next-generation instruments improve rare-cell detection, sterility control, biosafety, and throughput for translational applications. The post Advanced Cell Sorting Balances Precis...
D&D‑seq uses a base editor–nanobody fusion to record DNA–protein contacts at single‑cell resolution. The method maps transcription factor and chromatin-remodeling proteins. The...
Researchers are investigating the potential of CRISPR in relation to Down syndrome.
by Ioanna Morianou, Lee Phillimore, Bhavin S. Khatri, Louise Marston, Matthew Gribble, Austin Burt, Federica Bernardini, Andrew M. Hammond, Tony Nolan, Andrea Crisanti CRISPR-base...
ZoBio maintains that unlike transactional DEL screening approaches that focus solely on hit generation, its platform is designed to deliver biologically relevant, structurally char...
by Zachary Hemminger, Haley De Ocampo, Fangming Xie, Zhiqian Zhai, Jingyi Jessica Li, Roy Wollman Motivation Most imaging-based spatial transcriptomics methods measure individual g...
Sterile flies are crucial as the cattle industry fights New World screwworm, and a new technology could be the key to eradicating the pest. Stephanie Gamez, the research and deve...
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