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rna-seqblog.com /3 days ago

Researchers show how early RNA-based life may have repaired its genome, providing insight into the origins of life

A newly engineered ribozyme repairs broken RNA, creating new opportunities for studying RNA evolution while improving the detection of damaged molecules through RNA sequencing...

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lifespan.io /2 weeks ago

How a Primate-Specific RNA Strand Worsens Senescence

Researchers have discovered a primate-specific piece of non-coding RNA that is linked to aging and makes senescence worse. The packing matters While non-coding RNA strands (ncRNAs)...

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phys.org /3 days ago

RNA-only repair enzyme reveals how primordial life could have protected genomes

In most modern cells, DNA stores the genetic blueprint, and proteins replicate, repair and build from those blueprints. At the same time, proteins require instructions from DNA to...

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rna-seqblog.com /1 month ago

MSK scientists uncover RNA’s hidden role as protein chaperone

RNA sequencing continues to reveal unexpected RNA functions, including how mRNA 3′UTRs help regulatory proteins fold correctly and maintain proper cellular activity... The post MSK...

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bioengineer.org /1 month ago

RBM20 Isoform Control Shapes Splicing in Health

In the intricate landscape of genetic regulation, the study of RNA-binding proteins is unraveling new dimensions of molecular control mechanisms pivotal for development and disease...

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lifespan.io /1 month ago

CRISPR-Based System Targets RNA and Kills Cells on Demand

Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted assas...

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scitechdaily.com /4 days ago

Scientists Catch a “Jumping Gene” Moving Between Species

A jumping gene was directly observed moving from predator to prey through circular RNA. Dead cells are usually molecular dead ends: their fragile RNA messages rapidly disappear, an...

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journals.plos.org /1 month ago

Type II tRNA cleavage by SLFN14 endoribonuclease variants linked to inherited thrombocytopenia drives global translation...

by Chengchao Ding, Xinyi Ashley Liu, Fushun Zhang, Saori Uematsu, Shu-Bing Qian, Yan Xiang Schlafens proteins (SLFNs) are interferon-inducible regulators of RNA metabolism that in...

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scitechdaily.com /3 days ago

Strange “Chimeric” RNA Linked to Women’s Health and Wellness

A little-known RNA molecule found only in women may influence immunity, infection severity, and autoimmune risk. Some RNA molecules once dismissed as genetic mistakes may actually...

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journals.plos.org /1 month ago

The <i>Pseudomonas aeruginosa</i> ribonuclease Ribocin cleaves eukaryotic ribosomes at helix 69 to inhibit h...

by Alejandro Vasquez-Rifo, Denis Susorov, Emily H. Sholi, Gabriel Demo, Yasaman Jami, Jihui Sha, James A. Wohlschlegel, Andrei Korostelev, Victor Ambros Pseudomonas aeruginosa emp...

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rna-seqblog.com /3 weeks ago

Systematic benchmarking of dorado basecalling models for RNA modification detection

..Nanopore RNA sequencing models can detect RNA modifications, but benchmark results reveal significant false positives and highlight the importance of controls for accurate epitra...

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bioengineer.org /1 month ago

How Chaperones Build RNA Silencing Complexes

In a groundbreaking revelation that promises to reshape our understanding of gene regulation, scientists have decrypted the elusive structural dynamics of the RNA-induced silencing...

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genengnews.com /1 month ago

Defective HIV RNA Linked to Persistent Viremia During Long-Term ART

Studying blood samples from people living with HIV researchers found that most persistent cases of detectable viremia among those on long-term ART are due to defective, noninfectio...

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rna-seqblog.com /3 weeks ago

EclipseBio expands eCOMPASSâ„¢ platform with eSENSE Breakâ„¢ to map RNA fragmentation at nucleotide resolution

Eclipse Bioinnovations uses RNA sequencing in eSENSE Breakâ„¢ to map RNA fragmentation at single-nucleotide resolution, helping developers understand RNA stability and structural v...

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genengnews.com /3 weeks ago

Spotlight on RNA Therapeutics

This GEN Spotlight on RNA Therapeutics brings you three interlinked sessions that feature outstanding researchers exploring various aspects of RNA biology and therapeutics. The pos...

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lifespan.io /3 weeks ago

A Transcriptional Failure Leads to Systemic Inflammation

Researchers have found that bound pieces of RNA and DNA in the cytoplasm of senescent cells encourage these cells to secrete inflammatory factors. When transcription gets sticky As...

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fightaging.org /1 month ago

Products of Transfer RNA Cleavage are Essential for Stress Response Slowing of Aging

Biochemistry is enormously complex. The closer that researchers look, the more that they will find. Details remain incompletely mapped and understood at every level; there are only...

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neurosciencenews.com /1 month ago

RNA Origami and Nanopores Accurately Size ALS Genes

A new study introduces an innovative platform capable of accurately sizing the toxic repeat expansion mutations that drive muscular dystrophy, Huntington’s disease, and ALS.

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rna-seqblog.com /1 month ago

Nanopore sequencing advances pseudouridine detection in ribosomal RNA

Nanopore direct RNA sequencing enables accurate, site-specific quantification of pseudouridine modifications in human ribosomal RNA, expanding opportunities for large-scale epitran...

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rna-seqblog.com /3 weeks ago

segSHAPE: RNA secondary structure prediction from nanopore direct RNA sequencing

segSHAPE improves RNA sequencing signal alignment and modification detection, enabling more accurate secondary structure predictions from individual RNA molecules across multiple c...

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rna-seqblog.com /1 month ago

A hidden switch fine-tunes the heart’s elasticity

RNA sequencing reveals that RBM20 uses multiple transcription start sites, producing distinct protein isoforms that influence heart development, cardiomyopathy, and heart muscle fu...

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rna-seqblog.com /1 month ago

CAMP4 Therapeutics preprints pioneering study on regulatory RNA profiling and gene upregulation

RNA sequencing with regRNA Capture-seq identified thousands of regulatory RNAs and enabled new strategies to increase expression of disease-related genes using ASOs...

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bioengineer.org /1 month ago

Pathogen lncRNA Hijacks Rice miRNA for Virulence

In a groundbreaking study published in Nature, researchers have unveiled a sophisticated molecular interaction between rice plants and their fungal pathogens that could revolutioni...

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