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fightaging.org /1 day ago

PM20D1 Creates N-oleoyl-Leucine to Improve Clearance of Amyloid-β Aggregates by Microglia

Researchers here note a mechanism that encourages the innate immune cells known as microglia to better clear amyloid-β in the aging brain. The protein PM20D1 acts in the formation...

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fiercebiotech.com /3 weeks ago

A protective gene sent to the liver cleared amyloid from mouse brains, sparking hope for an Alzheimer’s gene therapy

The calling card of Alzheimer’s disease is a buildup of misfolded amyloid protein in the brain, but many medicines struggle to penetrate the barrier protecting the mind from outsid...

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fightaging.org /1 month ago

Reviewing the Inability of Anti-Amyloid Immunotherapies to Affect Alzheimer's Disease

In the context of Alzheimer's disease, the data for anti-amyloid immunotherapies, the most recent of which do effectively clear the aggregation of amyloid-β in the brain, is not co...

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fightaging.org /1 month ago

Data on the Effective Long Term Treatment of Transthyretin Amyloidosis

Transthyretin is one of a small number of proteins that can misfold and aggregate to cause pathology in tissues, primarily the cardiovascular system, but other organs as well once...

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newscientist.com /1 month ago

Novel approach to clearing brain waste shows promise for Alzheimer's

Boosting the brain's waste-disposal system is increasingly showing promise for Alzheimer's disease, with a study now suggesting that a novel approach eases brain deficits and sympt...

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emdocs.net /3 weeks ago

EM@3AM: Amyloidosis

The EM@3AM series returns with amyloidosis. The post EM@3AM: Amyloidosis appeared first on emDocs.

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arstechnica.com /1 month ago

What’s the deal with Alzheimer’s disease and amyloid?

For decades, scientists have concentrated on what now looks to be a blind alley.

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kidney-international.org /1 week ago

Therapeutic Efficacy and Antigenicity of a Novel PEGylated IgA Protease in Preclinical Models of IgA Nephropathy

IgA nephropathy is the most common primary glomerulonephritis worldwide, characterized by IgA deposition and a high risk of progression to kidney failure. While emerging therapies...

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scienceblog.com /1 month ago

Alzheimer’s Drugs Clear the Plaques but Leave Patients No Better Off

The brain scans look unambiguous. After 18 months of treatment, the amyloid plaques that riddle the brains of early Alzheimer’s patients are visibly reduced, sometimes dramatica...

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itmedia.co.jp /3 weeks ago

「脳内のゴミ掃除機能」壊す新たな一因を特定　抗体で狙い撃ち→マウスのアルツハイマー症状が改善

広州医科大学などに所属する研究者らが発表した論文「A brain-persistent DDR2-degrading antibody reverses Alzheimer’s pathologies by restoring brain fluid dynamics and metabolic cleara...

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arthroplastyjournal.org /2 weeks ago

Amyloid in Primary Hip Arthroplasty Specimens: An Opportunity for Early Detection of Amyloidosis?

Recent advances in pharmacologic therapies to treat amyloidosis demand renewed focus on early identification of patients who will benefit from these therapies. Incidental detection...

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sciencedaily.com /4 weeks ago

Boosting one protein helps the brain fight Alzheimer’s

Scientists have discovered a way to help the brain clean itself of harmful Alzheimer’s plaques by activating its own support cells. By increasing a protein called Sox9, researchers...

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sciencedaily.com /1 week ago

Scientists reverse Alzheimer’s in mice with breakthrough nanotechnology

A new nanotechnology treatment reversed Alzheimer’s symptoms in mice by restoring the brain’s natural cleanup system. The specially engineered nanoparticles helped clear toxic amyl...

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scitechdaily.com /1 month ago

Breakthrough Alzheimer’s Drug Rewires the Brain Instead of Just Clearing Plaques

An experimental drug is showing promise by targeting Alzheimer’s disease at the level of gene regulation. Researchers at the University of Barcelona have developed an experimental...

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bioengineer.org /1 month ago

Anti-amyloid Alzheimer’s drugs fail to demonstrate significant clinical benefits

Recent comprehensive analysis has cast significant doubt on the clinical value of drugs targeting amyloid beta proteins in the brains of individuals with mild cognitive impairment...

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itmedia.co.jp /1 month ago

注射1回で「脳内のごみ」大掃除に成功　米大学がアルツハイマー病の新治療をScienceで発表　マウスで実証

米ワシントン大学などに所属する研究者らがScienceで発表した論文「Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy」は、一度の投薬で脳の細胞を改造...

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fightaging.org /1 week ago

Cyclarity Therapeutics Reports Safety Data for 7-Ketocholesterol Clearance

Cyclarity Therapeutics has been processing safety data from a phase 1 safety trial of a cyclodextrin drug to bind 7-ketocholesterol, a toxic form of oxidized cholesterol that contr...

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neurosciencenews.com /2 weeks ago

Targeting Brain “Clean-up” Cells to Fight Dementia

Researchers discovered that dysregulated circadian rhythms cause microglia, the brain’s immune cells, to become "stress-primed" and malfunction. This state prevents them from clear...

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fightaging.org /4 days ago

An Update on Progress at Repair Biotechnologies, Developing Means to Regress Atherosclerotic Plaque

Atherosclerosis is the development of fatty plaques that narrow blood vessels and eventually rupture to cause a stroke or heart attack, the most common cause of human mortality. At...

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lifespan.io /1 month ago

Affecting a Signaling Pathway Alleviates Alzheimer’s in Mice

A new study shows that the overexpression of somatostatin (SST), a neuropeptide produced in neurons and acting mostly on microglia, lowers inflammation and amyloid β burden, improv...

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sciencedaily.com /1 week ago

Scientists found a hidden Alzheimer’s trigger and shut it down

A newly identified enzyme called IDOL could become a major new target in the fight against Alzheimer’s disease. Researchers found that removing it from neurons sharply reduced amyl...

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neurosciencenews.com /1 day ago

The Brain Waste System Disrupted by Alzheimer’s Mapped

A new study leverages an elegant genetic engineering technique to track the exact routes metabolic debris uses to exit the central nervous system.

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itmedia.co.jp /1 month ago

“脳のごみ”洗い流す量を10％弱増加させる薬の配合特定　人間で世界初の実証、認知症予防に　米チームが研究発表

米バイオテクノロジー企業Applied Cognitionや米ワシントン州立大学などに所属する研究者らが発表した論文「Pharmacological enhancement of glymphatic function in humans increases the clea...

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organicconsumers.org /3 weeks ago

This Simple Amino Acid Supplement Greatly Reduces Alzheimer’s Damage

May 04, 2026 | Source: Science Daily | by Kindai University Alzheimer's disease (AD) is a progressive brain disorder and a leading cause of dementia worldwide. Despite years of re...

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